PMID: 11605938Oct 19, 2001Paper

Interaction of volatile anesthetics with human Kv channels in relation to clinical concentrations

Anesthesiology
P FriederichB W Urban

Abstract

Recent evidence shows that inhibition of human Kv3 channels by intravenous anesthetics occurs at clinical concentrations. The effects of volatile anesthetics on these human ion channels are unknown. This study was designed to establish whether minimum alveolar concentrations (MAC) of halothane, enflurane, isoflurane, and desflurane exhibit effects on Kv3 channeLs. To obtain an indication whether these findings may be specific to Kv3 channels, the effects of enflurane and isoflurane on human Kv1.1 channels were also investigated. Kv3 channels natively expressed in SH-SY5Y cells and Kv1.1 channels expressed in HEK293 cells were measured with the whole cell patch clamp technique by standard protocols. Concentrations of volatile anesthetics were determined by gas chromatography. Halothane, enflurane, isoflurane, and desflurane reversibly inhibited Kv3 channels in a concentration-dependent manner. Concentrations at half-maximal effect (IC50 values) ranged between 1,800 and 4,600 microM. Hill coefficients were between 1.7 and 2.5. IC50 values for inhibition of Kv1.1 channels were 2,800 and 5,200 microM, and Hill coefficients were 3.9 and 5.6 for enflurane and isoflurane, respectively. Volatile anesthetics inhibit human Kv3 channels a...Continue Reading

References

Jun 22, 1987·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·B W Urban, D A Haydon
Apr 1, 1986·The Journal of Physiology·D A Haydon, B W Urban
Aug 1, 1981·Pflügers Archiv : European journal of physiology·O P HamillF J Sigworth
Oct 1, 1995·Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS·B W UrbanH C Wartenberg
Jul 22, 1999·Annals of the New York Academy of Sciences·W A CoetzeeB Rudy
Jul 22, 1999·Annals of the New York Academy of Sciences·B RudyE Vega-Saenz de Miera

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Citations

Oct 6, 2012·The Journal of Biological Chemistry·Annika F BarberManuel Covarrubias
Aug 24, 2010·British Journal of Anaesthesia·K MaurerD R Spahn
Apr 26, 2007·Anesthesia and Analgesia·Mark A Punke, Patrick Friederich
Mar 26, 2005·Anesthesiology·Renyu Liu, Roderic G Eckenhoff
Jun 7, 2003·European Journal of Anaesthesiology·P Friederich
Feb 18, 2006·Pharmacology & Therapeutics·Bernd W UrbanMartin Barann
Nov 21, 2015·Biophysical Journal·Manuel CovarrubiasRoderic G Eckenhoff
May 13, 2015·Acta Physiologica·M SalomonssonC M Sorensen
Aug 12, 2015·Der Anaesthesist·T Krönauer, P Friederich
Oct 4, 2011·Biophysical Journal·Annika F BarberManuel Covarrubias
Apr 8, 2015·PloS One·Jonathan MapelliAlbertino Bigiani
Sep 26, 2009·Toxicology Mechanisms and Methods·Barbara Wiśniowska, Sebastian Polak
Sep 6, 2003·American Journal of Physiology. Cell Physiology·Thanawath HarrisManuel Covarrubias
Dec 31, 2003·Receptors & Channels·P FriederichB W Urban
Aug 14, 2002·British Journal of Anaesthesia·A Scholz
Oct 26, 2018·Chemical Reviews·Victoria Oakes, Carmen Domene
Aug 14, 2002·British Journal of Anaesthesia·P FriederichB W Urban

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