PMID: 11321675Apr 26, 2001Paper

Interaction of Zn2+ with phospholipid membranes

Biophysical Chemistry
H BinderO Zschörnig

Abstract

To characterize the specificity of zinc binding to phospholipid membranes in terms of headgroup structure, hydration and phase behavior we studied the zwitterionic lipid 1-palmitoyl-2-oleoyl-phosphatidylcholine as a function of hydration at 30 degreesC in the presence and absence of ZnCl2. Zinc forms a 2:1-1:1 complex with the lipid, and in particular with the negatively charged phosphate groups. Zn2(+)-bridges between neighboring lipid molecules stabilize the gel phase of the lipid relative to the liquid-crystalline state. Upon Zn2+ binding the C-O-P-O-C- backbone of the lipid headgroup changes from a gauche/gauche into the trans/trans conformation and it loses roughly 50% of the hydration shell. The ability of the Zn2(+)-bound phosphate groups to take up water is distinctly reduced, meaning that the headgroups have become less hydrophilic. The energetic cost (on the scale of Gibbs free energy) for completely dehydrating the lipid headgroups is decreased by approximately 10 kJ/mole in the presence of Zn2+. The interaction of phospholipid headgroups with Zn2+ is conveniently described by a hydrated zinc-phosphate complex the key energy contribution of which is more covalent than electrostatic in nature. Dehydration of phospholi...Continue Reading

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Citations

Nov 8, 2006·European Biophysics Journal : EBJ·Hans Binder
Jun 6, 2002·Chemistry and Physics of Lipids·Hans Binder, Olaf Zschörnig
May 24, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Or SzekelyUri Raviv
Oct 16, 2007·Applied and Environmental Microbiology·Raffaele De NicolaPascale Daran-Lapujade
Nov 7, 2007·Molecular Medicine·Husnain K HaiderMuhammad Ashraf
Mar 25, 2011·Journal of Pharmacy & Bioallied Sciences·Sarantis Giatrellis, George Nounesis
Aug 3, 2005·Proceedings of the National Academy of Sciences of the United States of America·Hongjun LiangGerard C L Wong
Nov 5, 2011·Biochimica Et Biophysica Acta·Carla GasbarriAntonella Dalla Cort
Jul 19, 2011·Journal of Biotechnology·Xin-Qing Zhao, Feng-wu Bai
Apr 27, 2010·Molecular Immunology·Dennis C LefebvrePauline Johnson
Apr 30, 2016·The Journal of Physical Chemistry. a·Oren LotanUri Raviv
Oct 23, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Sjoerd HakKlaas Nicolay
Sep 11, 2002·The Journal of Gene Medicine·Chantal PichonPatrick Midoux
Mar 10, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Norbert KučerkaDaniela Uhríková
Mar 10, 2016·Electrophoresis·Shane S WellsChristopher R Harrison
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Aug 24, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kate L SeibIsabel Delany
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Oct 21, 2017·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Aneta D Petelska, Monika Naumowicz
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Jul 10, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Lea FinkUri Raviv

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