Interaction with the effector dynamin-related protein 1 (Drp1) is an ancient function of Rab32 subfamily proteins

Cellular Logistics
Carolina Ortiz-SandovalThomas Simmen

Abstract

The mitochondria-associated membrane (MAM) is an endoplasmic reticulum (ER) domain that forms contacts with mitochondria and accommodates Ca(2+) transfer between the two organelles. The GTPase Rab32 regulates this function of the MAM via determining the localization of the Ca(2+) regulatory transmembrane protein calnexin to the MAM. Another function of the MAM is the regulation of mitochondrial dynamics mediated by GTPases such as dynamin-related protein 1 (Drp1). Consistent with the importance of the MAM for mitochondrial dynamics and the role of Rab32 in MAM enrichment, the inactivation of Rab32 leads to mitochondrial collapse around the nucleus. However, Rab32 and related Rabs also perform intracellular functions at locations other than the MAM including melanosomal trafficking, autophagosome formation and maturation, and retrograde trafficking to the trans-Golgi network (TGN). This plethora of functions raises questions concerning the original cellular role of Rab32 in the last common ancestor of animals and its possible role in the last eukaryotic common ancestor (LECA). Our results now shed light on this conundrum and identify a role in Drp1-mediated mitochondrial dynamics as one common denominator of this group of Rabs, ...Continue Reading

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Citations

Jan 25, 2017·Journal of Neuroinflammation·Yohannes HaileThomas Simmen
Jan 19, 2017·International Journal of Molecular Sciences·Chenxia HuLanjuan Li
Apr 8, 2017·Journal of Cell Science·Divya VenkateshMark C Field
Jan 15, 2019·PloS One·Dieter WaschbüschAngelika Barnekow
Sep 14, 2018·Cell Death and Differentiation·Roberto Bravo-SaguaSergio Lavandero
Jan 27, 2017·Biology Direct·Maria Sol Herrera-Cruz, Thomas Simmen
Oct 21, 2018·International Journal of Molecular Sciences·Atsushi Saito, Kazunori Imaizumi
Jun 20, 2018·Cellular and Molecular Life Sciences : CMLS·Qingtian LiDavid Sheikh-Hamad
Feb 7, 2020·Oncogene·Saranya NavaneethaKrishnanKi-Young Lee
Jan 19, 2021·BioMed Research International·Hanwen ZhangWei Li
Mar 23, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Alejandro Silva-PalaciosJosé Pedraza-Chaverri
Apr 13, 2021·Frontiers in Endocrinology·Ugochukwu Kelvin IhenachoR Blake Hill

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Methods Mentioned

BETA
GTPase
GTPases
co-immunoprecipitation

Software Mentioned

MacClade
Phylip
ImageJ
BLAST
ImageJ Coloc
Sequencher
PhyML
RAxML
Coulson Plot Generator
MUSCLE

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