PMID: 8443039Feb 1, 1993Paper

Interactions among primaquine, malaria infection and other antimalarials in Thai subjects

British Journal of Clinical Pharmacology
G EdwardsN J White

Abstract

1. The pharmacokinetics of rac-primaquine (45 mg base) and its principal plasma metabolite, carboxyprimaquine have been investigated in healthy Thai adults prior to and following a single oral dose of mefloquine (10 mg kg-1). 2. Primaquine was rapidly absorbed, attaining peak plasma concentrations (median and range) of 167 (113-532) micrograms l-1 in 2 (1-4) h. Thereafter, concentrations declined rapidly with an apparent terminal half-life of 6.1 (1.7-16.1) h and an oral clearance (CLpo) of 33.1 (17.6-49.3) l h-1. Administration of mefloquine had no effect on the values of any of these parameters at the 5% level of significance [Cmax 229 (114-503) micrograms l-1; tmax 3 (2-4) h; t1/2,z 3.9 (1.7-13.5) h; CLpo 34.0 (21.7-49.0) l h-1]. 3. The carboxylic acid metabolite of primaquine achieved maximum concentrations (median and range) of 890 (553-3634) micrograms l-1 at 6 (3-16) h. Thereafter, plasma concentrations of carboxyprimaquine declined to 346 (99-918) micrograms l-1 at 24 h. AUC (0,24 h) was 12737 (6837-27388) micrograms l-1 h. Administration of mefloquine had no effect on the plasma concentrations of this metabolite [Cmax 1035 (174-3015) micrograms l-1; tmax 8 (2-24) h; AUC(0,24) 13471 (2132-17863) micrograms l-1 h]. 4. Th...Continue Reading

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Citations

Jun 26, 2001·European Journal of Drug Metabolism and Pharmacokinetics·K Na-BangchangS Saenglertsilapachai
Mar 1, 1994·Transactions of the Royal Society of Tropical Medicine and Hygiene·K N BangchangJ Karbwang
Jul 4, 2001·Clinical Pharmacokinetics·P T Giao, P J de Vries
Jan 1, 1994·Drug Metabolism Reviews·M S Benedetti, P Dostert
May 3, 2011·FEBS Letters·Ines PetersenMichael Lanzer
Dec 14, 2011·Journal of Pharmaceutical Sciences·Anita NairJennifer B Dressman
Nov 28, 2012·The Lancet Infectious Diseases·Nicholas J White
Apr 9, 2008·Médecine et maladies infectieuses·M OliverS Picot
Sep 6, 2005·Biochemical Pharmacology·Patrick G BrayLeann Tilley
Nov 12, 2014·Antimicrobial Agents and Chemotherapy·Podjanee JittamalaJoel Tarning
Sep 14, 2016·Malaria Journal·Pius S FasinuLarry A Walker
Apr 2, 2014·Antimicrobial Agents and Chemotherapy·Sasithon PukrittayakameeNicholas J White
Nov 1, 2018·Revista Do Instituto De Medicina Tropical De São Paulo·Amanda Gabryelle Nunes Cardoso MelloJosé Luiz Fernandes Vieira
Nov 30, 2019·Journal of Travel Medicine·Jelena LewisJeff Goad
Jul 9, 2020·Parasitology Research·J O AdebayoS O Malomo
Aug 18, 2016·Expert Review of Anti-infective Therapy·Cindy S Chu, Nicholas J White
Jan 6, 2021·Current Drug Metabolism·Ana C A X De-Oliveira, Francisco J R Paumgartten

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