Interactions between a luminescent conjugated oligoelectrolyte and insulin during early phases of amyloid formation

Macromolecular Bioscience
Jens WigeniusOlle Inganäs

Abstract

Aggregates of misfolded proteins play an important role in diseases such as Alzheimer's. Here it is demonstrated how the anionic oligothiophene p-FTAA interacts with and influences pre-fibrillar protein assemblies during the earlier stages of in vitro fibrillation. Conjugated polythiophenes have previously been demonstrated to detect and discriminate between different types of protein aggregates and also introduce luminescent or conductive properties to these nanoscale fiber structures. Fluorescence spectroscopy, DLS, TEM and FCS are employed to follow the interplay between p-FTAA and insulin during in vitro fibrillation.

References

Feb 3, 1998·Cellular and Molecular Life Sciences : CMLS·L C SerpellC C Blake
Dec 20, 2003·Nature·Christopher M Dobson
Feb 17, 2006·Neurobiology of Aging·Charles G Glabe
Jan 31, 2007·Small·Anna HerlandOlle Inganäs
May 3, 2007·PLoS Biology·Bente VestergaardDmitri I Svergun
Aug 8, 2007·Journal of Structural Biology·Minna GroenningSven Frokjaer
Aug 31, 2007·BMC Bioinformatics·Aleksey Porollo, Jaroslaw Meller
Aug 7, 2010·Nanoscale·Mahiar HamediDaniel Aili

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Citations

Mar 13, 2013·Accounts of Chemical Research·John D Tovar
Jun 8, 2012·Chemical Reviews·Chunlei ZhuShu Wang
May 19, 2017·Biochemistry·Piotr Hanczyc, Lech Sznitko
Mar 1, 2016·Chemical Science·Chelsea CataniaGuillermo C Bazan
Apr 15, 2020·ACS Applied Materials & Interfaces·Edward R JiraCharles M Schroeder

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