Jan 1, 1976

Interactions between aminoglycoside antibiotics and carbenicillin or ticarillin

Infection
H A HoltD S Reeves

Abstract

Carbenicillin or ticarcillin were incubated individually with each of the following antibiotics: gentamicin, tobramycin, sisomicin, amikacin. The residual activity of each aminoglycoside in this mixture was assayed enzymatically. Amikacin was inactivated the least of the aminoglycosides. Both penicillins inactivated each aminoglycoside to a similar extent by a degree which varied according to the medium of incubaiton, the least inactivation being seen in pooled human serum and the most in phosphate buffer at pH 7.4.

Mentioned in this Paper

Aminoglycoside [EPC]
Phosphate buffers
Gentavet
Gentamicins
Aminoglycosides
Bacteriocidal Agents
Antibiotic throat preparations
A.M.K
Antifungal Antibiotics, Topical
Sisomicin

About this Paper

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