PMID: 11334837May 4, 2001Paper

Interactions between antiarrhythmic drugs and cardiac memory

Cardiovascular Research
Alexei N PlotnikovMichael R Rosen

Abstract

Ventricular pacing or arrhythmias can induce cardiac memory (CM). We hypothesized that clinically administered antiarrhythmic drugs alter the expression of CM, and that the repolarization changes characteristic of CM can modulate the effects of antiarrhythmic drugs. We studied conscious, chronically-instrumented dogs paced for two 1-h periods to study the effects of drugs on the evolution of memory (protocol 1) or for 21 days (protocol 2) to observe the effects of steady-state memory on drug actions. Dogs were treated in both settings with quinidine, lidocaine or E4031, in random order, and within therapeutic serum concentration ranges. Pacing, alone, for 2 h significantly prolonged ERP only near the left ventricular pacing site, whereas pacing alone for 21 days prolonged ERP at all sites (P<0.05). Quinidine and E4031, but not lidocaine, prolonged repolarization and ERP and suppressed evolution of CM in protocol 1. However, quinidine's effect in prolonging repolarization was diminished in both protocols, while its effect in prolonging ERP was diminished in the 21-day protocol only. In contrast, the effects of E4031 were additive to those of CM, prolonging repolarization and ERP in both protocols, while lidocaine showed no chang...Continue Reading

Citations

Aug 23, 2002·Pharmacology & Therapeutics·Michael Rosen, Alexei Plotnikov
Jun 30, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Alexei ShvilkinMark E Josephson
Mar 3, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Morten B ThomsenMichael R Rosen
Nov 13, 2007·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Liliane WeckeLennart Bergfeldt
Mar 8, 2007·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Tobias OpthofMichiel J Janse
Apr 7, 2015·Trends in Cardiovascular Medicine·Michael R Rosen, Lennart Bergfeldt
Dec 13, 2005·Journal of Internal Medicine·M R Rosen, I S Cohen
Apr 27, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Dirk VollmannMaurits Allessie
Jun 15, 2016·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·George BazoukisPanagiotis Korantzopoulos
Dec 20, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Kornelis W PatbergMichael R Rosen
Nov 11, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Michael R Rosen
Nov 15, 2005·The Journal of Physiology·Michael R Rosen, Ira S Cohen
Feb 27, 2007·International Journal of Cardiology·Kun-Tai LeeWen-Ter Lai
Oct 15, 2014·Circulation. Arrhythmia and Electrophysiology·Raphael RossoSami Viskin
Apr 23, 2015·Circulation. Arrhythmia and Electrophysiology·Alexei ShvilkinMark E Josephson
Mar 11, 2009·Pacing and Clinical Electrophysiology : PACE·Mohammad KooshkabadiJonathan Langberg
Feb 27, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Kun-Tai LeeWen-Ter Lai

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