Interactions between Atrial Fibrillation, Cardiovascular Risk Factors, and ApoE Genotype in Promoting Cognitive Decline in Patients with Alzheimer's Disease: A Prospective Cohort Study

Journal of Alzheimer's Disease : JAD
Lorenzo FalsettiMauro Silvestrini

Abstract

An association between non-valvular atrial fibrillation (NVAF) and cognitive impairment has been hypothesized. We sought to evaluate whether and how permanent NVAF (pNVAF) is associated with progression of cognitive impairment in patients with Alzheimer's disease (AD) in the presence of vascular or genetic risk factors. 310 consecutive patients affected by mild-moderate AD were included and followed for a 24-month period. At the end of the follow-up, based on the results of the neuropsychological evaluation patients were classified as stable or deteriorated to severe AD. Clinical history, therapy, time in therapeutic range for anticoagulation, Framingham cardiovascular risk profile (FCRP), CHA2DS2-VASc score, Mini-Mental State Examination (MMSE), ApoE genotype, brain CT-scan, carotid ultrasound, and ECG were collected. Binary logistic and path analysis were adopted to assess relationships between pNVAF, ApoE, and cognitive outcome. Despite anticoagulant therapy, pNVAF was associated with lower entry MMSE, higher mean intima-media thickness (mIMT) and higher FCRP. Among patients carrying ApoE ɛ4 allele and affected by pNVAF, the lowest MMSE (14.90±7.62) and the highest mIMT (1.16±0.17 mm) and FCRP (26.24±3.96) values were detect...Continue Reading

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Oct 2, 2019·Current Opinion in Cardiology·Oxana GalenkoT Jared Bunch
Nov 30, 2019·Current Atherosclerosis Reports·Zhaojia WangTong Liu
Aug 9, 2018·Frontiers in Aging Neuroscience·Tamas FulopEric H Frost
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Jan 19, 2021·Journal of Alzheimer's Disease : JAD·David A Loeffler
Apr 18, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Giovanna Viticchi, Mauro Silvestrini
Jul 27, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Caterina MottaAlessandro Martorana
Oct 1, 2021·Lipids in Health and Disease·Xunwei DengZhixiong Zhong

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Methods Mentioned

BETA
PCR

Software Mentioned

SPSS
Power
SPSS Amos
MedCalc
mIMT
QLAB

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