PMID: 9643480Jun 27, 1998Paper

Interactions between bacterial toxins and intestinal cells

Toxicon : Official Journal of the International Society on Toxinology
M R Popoff

Abstract

Bacterial toxins which act on intestinal cells display a great diversity of size, structure and mode of action. Some toxins interact with the cell by transducing a signal across the membrane leading to stimulation of intracellular second messenger (E. coli heat stable enterotoxin), others form pores (C. perfringens enterotoxin, ...) permitting the leakage of cellular components and cell lysis. The most sophisticated toxins comprise at least two functional domains or components, one being a binding domain permitting the internalization into the cell of an enzymatic domain which modifies an intracellular target. The enzymatic modification (ADP-ribosylation, UDP-glucosylation, glycohydrolysis, proteolysis, ...) of a specific target (heterotrimeric G-protein, small G-protein, monomeric actin, ribosomal RNA, ...) alters the cell physiology (increase of ions and water secretion, cytoskeleton rearrangement, protein synthesis inhibition, apoptosis, ...) and tissue organization (modification of barrier permeability, necrosis, ...). The study of bacterial toxins leads to the understanding of the interactions between pathogenic bacteria and their hosts and constitutes also a new approach in cell biology, by facilitating the exploration of...Continue Reading

References

Feb 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M G CurrieC E Smith
Jul 1, 1992·Canadian Journal of Microbiology·C L Gyles
Oct 1, 1992·Molecular Microbiology·K Aktories, A Wegner
Apr 1, 1992·Infection and Immunity·R L Van TassellT D Wilkins
Jun 1, 1992·Experimental Cell Research·K Sandvig, B van Deurs
May 1, 1992·Molecular & General Genetics : MGG·C von Eichel-StreiberM Sauerborn
Feb 1, 1992·Infection and Immunity·B BaudryJ B Kaper
May 1, 1991·Infection and Immunity·D J Beecher, J D Macmillan
Oct 1, 1991·Infection and Immunity·W A FlegelH Northoff
Jan 1, 1991·Toxicon : Official Journal of the International Society on Toxinology·C Fiorentini, M Thelestam
Jan 1, 1991·Toxicon : Official Journal of the International Society on Toxinology·R V Considine, L L Simpson
May 11, 1990·Science·P Marrack, J Kappler
Jan 1, 1990·Clinical Microbiology Reviews·C L Hatheway
May 1, 1988·Microbial Pathogenesis·B A McClaneA P Wnek
Sep 1, 1988·Infection and Immunity·M R PopoffP Boquet
Jan 1, 1988·Clinical Microbiology Reviews·D M LyerlyT D Wilkins
Dec 1, 1987·The American Journal of Physiology·J L MadaraS Carlson
May 1, 1986·The Journal of Infection·S BabudieriG Panichi
Jul 24, 1986·Nature·K AktoriesE Habermann
Jan 1, 1984·Infection and Immunity·I Ohishi, Y Odagiri
Nov 7, 1995·Proceedings of the National Academy of Sciences of the United States of America·A NusratJ L Madara
May 23, 1995·Proceedings of the National Academy of Sciences of the United States of America·X L RudnerJ S Almenoff
Jun 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C L SearsR L Van Tassell
Nov 1, 1995·Infection and Immunity·D J BeecherA C Wong
Aug 25, 1995·Journal of Molecular Biology·R G ZhangE M Westbrook
May 1, 1995·The Journal of Infection·C D InwardC M Taylor

❮ Previous
Next ❯

Citations

Aug 2, 2000·Proceedings of the National Academy of Sciences of the United States of America·K KunzelmannD I Cook
Dec 10, 1999·Proceedings of the National Academy of Sciences of the United States of America·E D SegalL S Tompkins
Nov 5, 2013·European Journal of Pharmacology·Dong-Liang Hu, Akio Nakane
Oct 7, 2006·Current Opinion in Gastroenterology·A Fasano
Apr 12, 2008·Purinergic Signalling·Cristiana StefanMathieu Bollen
Dec 2, 2008·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·H Bosche, N Schmeisser
Jun 21, 2001·Proceedings. Biological Sciences·J H Fullard
Sep 12, 2000·Current Gastroenterology Reports·L R Schiller
Apr 27, 2021·Toxicon : Official Journal of the International Society on Toxinology·Nicol StrakovaRenata Karpiskova
Mar 20, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Bryan DelaneyUNKNOWN ILSI International Food Biotechnology Committee Task Force on Protein Safety

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Bioscience, Biotechnology, and Biochemistry
Mayumi NakamuraKiichiro Totani
Princess Takamatsu Symposia
M IkejimaD M Gill
Biochemical and Biophysical Research Communications
S HippenstielN Suttorp
© 2022 Meta ULC. All rights reserved