Interactions between behaviorally relevant rhythms and synaptic plasticity alter coding in the piriform cortex.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Anne-Marie M Oswald, Nathaniel N Urban

Abstract

Understanding how neural and behavioral timescales interact to influence cortical activity and stimulus coding is an important issue in sensory neuroscience. In air-breathing animals, voluntary changes in respiratory frequency alter the temporal patterning olfactory input. In the olfactory bulb, these behavioral timescales are reflected in the temporal properties of mitral/tufted (M/T) cell spike trains. As the odor information contained in these spike trains is relayed from the bulb to the cortex, interactions between presynaptic spike timing and short-term synaptic plasticity dictate how stimulus features are represented in cortical spike trains. Here, we demonstrate how the timescales associated with respiratory frequency, spike timing, and short-term synaptic plasticity interact to shape cortical responses. Specifically, we quantified the timescales of short-term synaptic facilitation and depression at excitatory synapses between bulbar M/T cells and cortical neurons in slices of mouse olfactory cortex. We then used these results to generate simulated M/T population synaptic currents that were injected into real cortical neurons. M/T population inputs were modulated at frequencies consistent with passive respiration or acti...Continue Reading

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Citations

Jan 29, 2013·Journal of Computational Neuroscience·Steven Reich, Robert Rosenbaum
May 8, 2013·Trends in Neurosciences·John M Bekkers, Norimitsu Suzuki
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Sep 12, 2015·Journal of Neurophysiology·Yiyi YuNathaniel N Urban
Apr 8, 2020·Journal of Mathematical Neuroscience·Valentin SchmutzTilo Schwalger

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