Interactions between chromosomes, microfilaments and microtubules revealed by the study of small GTPases in a big cell, the vertebrate oocyte

Molecular and Cellular Endocrinology
Marie-Hélène Verlhac, Julien Dumont

Abstract

Meiotic divisions during oogenesis in higher eukaryotes are extremely asymmetric giving rise to one gamete, the oocyte, and two polar bodies. In most species, this asymmetric partitioning relies on the eccentric positioning of meiotic spindles. Recent work performed in mouse and frog oocytes has suggested the involvement of small GTPases, such as Cdc42, Rac and Ran both in the control of spindle organization and positioning. The present review summarizes these findings that shed light on the molecular mechanisms by which small GTPases control asymmetric cell divisions in vertebrate oocytes.

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Citations

Jun 15, 2013·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Shao-Chen Sun, Nam-Hyung Kim
Mar 30, 2011·Human Reproduction Update·Maurizio ZuccottiSilvia Garagna
May 19, 2010·Marine Drugs·Francesco Silvestre, Elisabetta Tosti
Apr 7, 2012·Trends in Cell Biology·Julien Dumont, Arshad Desai
Oct 11, 2012·Cytoskeleton·Shawn N Jordan, Julie C Canman
Jan 26, 2012·Developmental Neurobiology·Karine ParainMuriel Perron
Aug 29, 2012·Cytoskeleton·Amy Shaub MaddoxJulien Dumont
Feb 14, 2012·Biochimica Et Biophysica Acta·Yoichi MiyamotoKate L Loveland
Mar 3, 2012·Clinical and Experimental Reproductive Medicine·Sojung Kwon, Hyunjung J Lim
Sep 29, 2020·Journal of Cellular Biochemistry·Chun-Xiang ZhouZheng-Rong Xia
Dec 17, 2009·Experimental Cell Research·Dan YuXi Zhan

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