Interactions between CXCR4 and CXCL12 promote cell migration and invasion of canine hemangiosarcoma

Veterinary and Comparative Oncology
K S ImJ-H Kim

Abstract

The CXCR4/CXCL12 axis plays an important role in cell locomotion and metastasis in many cancers. In this study, we hypothesized that the CXCR4/CXCL12 axis promotes migration and invasion of canine hemangiosarcoma (HSA) cells. Transcriptomic analysis across 12 HSA cell lines and 58 HSA whole tumour tissues identified heterogeneous expression of CXCR4 and CXCL12, which was associated with cell movement. In vitro, CXCL12 promoted calcium mobilization, cell migration and invasion that were directly proportional to surface expression of CXCR4; furthermore, these responses proved sensitive to the CXCR4 antagonist, AMD3100, in HSA cell lines. These results indicate that CXCL12 potentiates migration and invasion of canine HSA cells through CXCR4 signalling. The direct relationship between these responses in HSA cells suggests that the CXCR4/CXCL12 axis contributes to HSA progression.

References

Oct 1, 1978·Journal of Comparative Pathology·A Oksanen
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Sep 30, 2000·Journal of Veterinary Internal Medicine·C A CliffordC J Henry
Feb 21, 2002·Trends in Cell Biology·Angela GladingAlan Wells
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Dec 24, 2002·Seminars in Immunology·Fran Balkwill
May 2, 2003·Nature Reviews. Cancer·Peter Friedl, Katarina Wolf
Jul 31, 2003·The Journal of Biological Chemistry·Leo S PriceJohn G Collard
Nov 19, 2003·Biochemical and Biophysical Research Communications·Reinhard HenschlerDietrich Möbest
Dec 6, 2003·Science·Anne J RidleyAlan Rick Horwitz
Dec 31, 2003·Developmental Biology·Myrto Raftopoulou, Alan Hall
Jan 27, 2004·Nature Cell Biology·Donna J WebbAlan F Horwitz
Apr 6, 2004·Laboratory Investigation; a Journal of Technical Methods and Pathology·Susan P FosmireJaime F Modiano
Apr 14, 2004·Genes & Development·Arnaud BessonJames M Roberts
Jul 2, 2004·Nature Reviews. Cancer·Fran Balkwill
Dec 14, 2004·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Patricia C Schultheiss
Mar 29, 2005·Nature Cell Biology·Zhong LiDianqing Wu
Jan 13, 2006·Oncogene·M EhteshamR C Thompson
Jun 27, 2006·Experimental Hematology·Angela R Lamerato-KozickiJaime F Modiano
Aug 31, 2006·The Journal of Experimental Medicine·Jennifer M BurnsThomas J Schall
May 10, 2008·Journal of Veterinary Internal Medicine·T M FanL D Garrett
Jun 5, 2008·The Journal of Pathology·A Zlotnik
Nov 5, 2008·Journal of Experimental & Clinical Cancer Research : CR·Enrico P SpugniniAlfonso Baldi
Nov 28, 2008·International Journal of Cancer. Journal International Du Cancer·Yoichi MatsuoSushovan Guha
Oct 29, 2009·Current Pharmaceutical Design·Roeliene C KruizingaAnnemiek M E Walenkamp
Apr 13, 2010·Journal of Experimental & Clinical Cancer Research : CR·Ke ZhengGuo-Sheng Ren
Sep 15, 2010·Cancer Metastasis Reviews·Xueqing SunJianhua Wang
Sep 3, 2011·Cold Spring Harbor Perspectives in Biology·Anna Huttenlocher, Alan Rick Horwitz
Apr 5, 2013·International Journal of Cancer. Journal International Du Cancer·Jill T SchappaJaime F Modiano
Sep 13, 2013·Molecular Cancer Research : MCR·Young H ChoiRobert M Strieter
Sep 21, 2013·Nature·Corbin E Meacham, Sean J Morrison
Sep 24, 2013·Human Pathology·Liping LiuSamuel M Cohen
Mar 4, 2014·Experimental Cell Research·Jong-Hyuk KimJaime F Modiano
Jan 31, 2015·The Veterinary Journal·Lisa Y Pang, David J Argyle

❮ Previous
Next ❯

Citations

Jun 3, 2016·Journal of Veterinary Internal Medicine·M L ByrumT M Fan
Jun 10, 2020·Veterinary and Comparative Oncology·Ber-In LeeMary-Keara Boss
Aug 23, 2018·Veterinary and Comparative Oncology
Nov 6, 2015·Veterinary Sciences·Jong-Hyuk KimJaime F Modiano
Sep 21, 2015·Veterinary Sciences·Erin B Dickerson, Brad A Bryan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Actin, Myosin & Cell Movement

Contractile forces generated by the actin-myosin cytoskeleton are critical for morphogenesis, but the cellular and molecular mechanisms of contraction have been elusive for many cell shape changes and movements. Here is the latest research on the roles of actin and myosin in cell movement.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.