Interactions between cytokines and neurohormonal systems in the failing heart

Heart Failure Reviews
H Kan, M S Finkel

Abstract

The prognosis for patients with congestive heart failure (CHF) has been improved as a result of the use of angiotensin converting enzyme inhibitors and beta-adrenergic receptor blockers. The success of these therapies underscores the pathogenic role of neurohormonal activation in CHF. Clinical and experimental evidence supports a pathophysiologic role for pro-inflammatory cytokines and nitric oxide (NO) in the effects of angiotensin II and norepinephrine in CHF. Potential mechanism(s) responsible for the effects of these immunomodulators can be explained on the basis of established principles of myocardial excitation contraction coupling (E-C). A novel hypothesis is proposed that cytokines and NO-mediated alterations in E-C coupling contribute to the reversible myocardial depression and beta-adrenergic desensitization observed in a diverse group of clinical conditions that activate host inflammatory responses, including CHF. Basic studies into cytokine signaling pathways in cardiac myocytes have the potential to provide important new insights relevant to the design of new management strategies for the treatment of congestive heart failure patients.

Citations

Feb 25, 2003·Journal of Cellular Physiology·Hong Kan, Mitchell S Finkel
Dec 15, 2005·Critical Care Medicine·Hong KanMitchell S Finkel
Mar 7, 2008·Wiener klinische Wochenschrift·Mahmoud Umar Sani
Mar 21, 2002·Critical Care Medicine·Mitchell S Finkel
Oct 7, 2004·Journal of Applied Physiology·Hong KanMitchell S Finkel
Oct 14, 2008·Cardiovascular Toxicology·Youxi YuanMitchell S Finkel
Dec 9, 2003·American Journal of Physiology. Cell Physiology·Hong KanMitchell S Finkel
Apr 21, 2010·Heart Failure Reviews·Mona HedayatNima Rezaei
Oct 31, 2006·American Heart Journal·Mette Elise EstensenTorbjørn Omland

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