Interactions between dietary oil treatments and genetic variants modulate fatty acid ethanolamides in plasma and body weight composition

The British Journal of Nutrition
Shuaihua PuPeter Jh Jones

Abstract

Fatty acid ethanolamides (FAE), a group of lipid mediators derived from long-chain fatty acids (FA), mediate biological activities including activation of cannabinoid receptors, stimulation of fat oxidation and regulation of satiety. However, how circulating FAE levels are influenced by FA intake in humans remains unclear. The objective of the present study was to investigate the response of six major circulating FAE to various dietary oil treatments in a five-period, cross-over, randomised, double-blind, clinical study in volunteers with abdominal obesity. The treatment oils (60 g/12 552 kJ per d (60 g/3000 kcal per d)) provided for 30 d were as follows: conventional canola oil, high oleic canola oil, high oleic canola oil enriched with DHA, flax/safflower oil blend and corn/safflower oil blend. Two SNP associated with FAE degradation and synthesis were studied. Post-treatment results showed overall that plasma FAE levels were modulated by dietary FA and were positively correlated with corresponding plasma FA levels; minor allele (A) carriers of SNP rs324420 in gene fatty acid amide hydrolase produced higher circulating oleoylethanolamide (OEA) (P=0·0209) and docosahexaenoylethanolamide (DHEA) levels (P=0·0002). In addition, e...Continue Reading

References

Feb 1, 1990·The American Journal of Clinical Nutrition·M D MifflinY O Koh
Jun 23, 1980·Biochimica Et Biophysica Acta·D E EppsH O Schmid
May 17, 2001·Proceedings of the National Academy of Sciences of the United States of America·A BergerV Di Marzo
Nov 9, 2001·Nature·F Rodríguez de FonsecaD Piomelli
Dec 31, 2002·Chemistry and Physics of Lipids·Harald H O SchmidEvgueni V Berdyshev
Jan 30, 2004·The American Journal of Clinical Nutrition·Christine L PelkmanPenny M Kris-Etherton
Mar 17, 2005·Cellular and Molecular Life Sciences : CMLS·J Lo VermeD Piomelli
Apr 6, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J C SipeE Beutler
May 3, 2005·Nature Reviews. Immunology·Thomas W Klein
Sep 14, 2006·Pharmacological Reviews·Pál PacherGeorge Kunos
Jan 12, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Dorit P JensenOluf Pedersen
Feb 19, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Gabriella AvielloAngelo A Izzo
Aug 16, 2008·Lipids·Clémentine ThabuisFrédéric Destaillats
Oct 1, 2008·Analytical Biochemistry·Timothy H MarczyloJustin C Konje
Jan 10, 2009·Obesity·Laurence HoareauRégis Roche
Aug 20, 2009·The Journal of Biological Chemistry·Nicoletta PasquarielloMauro Maccarrone
Oct 21, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Thi Ai DiepHarald Severin Hansen
Feb 2, 2011·The Biochemical Journal·Hee-Yong KimBill X Huang
Jul 16, 2011·The Journal of Biological Chemistry·Rong YangCharles N Serhan
Nov 13, 2012·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Lin LinPeter J H Jones
Feb 12, 2013·CNS & Neurological Disorders Drug Targets·Kazuhito TsuboiNatsuo Ueda
Mar 21, 2013·Pharmacological Reviews·Jacqueline L Blankman, Benjamin F Cravatt
Apr 11, 2013·Journal of Neurochemistry·Mohammad A RashidHee-Yong Kim
Jun 14, 2013·International Journal of Endocrinology·Shaan S NaughtonAndrew J McAinch
Jul 17, 2013·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Lin LinPeter J H Jones
Sep 18, 2013·Molecular Psychiatry·M PeciñaJ K Zubieta
Dec 24, 2013·European Journal of Nutrition·Sridevi Krishnan, Jamie A Cooper
Apr 22, 2014·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Iffat Ara Sonia RahmanNatsuo Ueda
May 11, 2015·The Journal of Pain : Official Journal of the American Pain Society·Christopher E RamsdenJoseph R Hibbeln

❮ Previous
Next ❯

Citations

Apr 9, 2017·Progress in Lipid Research·Kate J BowenPeter J H Jones
Mar 4, 2017·Physiology & Behavior·Jacob D BrownJulio E Ayala
Jun 3, 2018·British Journal of Clinical Pharmacology·Lihi Bar-Lev SchleiderVictor Novack
Dec 24, 2019·Clinical and Experimental Pharmacology & Physiology·Helda TutunchiAlireza Ostadrahimi
Jul 19, 2017·Annual Review of Nutrition·Nicholas J Schork, Laura H Goetz
Mar 30, 2019·Genes & Nutrition·Mar Garcia-AloyCristina Andres-Lacueva
Jul 14, 2019·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Jyoti Sihag, Peter J H Jones
May 22, 2020·Combinatorial Chemistry & High Throughput Screening·Mersedeh ShayanZahra Tayarani-Najaran

❮ Previous
Next ❯

Related Concepts

Related Feeds

Ataxias

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on different types of ataxias here.