Interactions between DNA and Gemini surfactant: impact on gene therapy: part I

Nanomedicine
Taksim AhmedShawn D Wettig

Abstract

Nonviral gene therapy using gemini surfactants is a unique approach to medicine that can be adapted toward the treatment of various diseases. Recently, gemini surfactants have been utilized as candidates for the formation of nonviral vectors. The chemical structure of the surfactant (variations in the alkyl tail length and spacer/head group) and the resulting physicochemical properties of the lipoplexes are critical parameters for efficient gene transfection. Moreover, studying the interaction of the surfactant with DNA can help in designing an efficient vector and understanding how transfection complexes overcome various cellular barriers. Part I of this review provides an overview of various types of gemini surfactants designed for gene therapy and their transfection efficiency; and Part II will focus on different novel methods utilized to understand the interactions between the gemini and DNA in a lipoplex.

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Citations

Oct 22, 2016·Journal of Colloid and Interface Science·Emilia FisicaroMarie Pierre Krafft
Apr 11, 2017·Physical Chemistry Chemical Physics : PCCP·M S IslamS D Wettig
Apr 15, 2017·Journal of Mass Spectrometry : JMS·M Al-Dulaymi, A El-Aneed
Apr 4, 2021·International Journal of Molecular Sciences·Damian NeubauerWojciech Kamysz
May 8, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Abdullah O Ba-Salem, Jean Duhamel
Jul 3, 2021·Nanomaterials·Natalia Sánchez-ArribasAndrés Guerrero-Martínez
Jul 25, 2021·International Journal of Molecular Sciences·Żaneta PolańskaMaciej Kozak
Dec 12, 2017·The Journal of Physical Chemistry. B·Samantha M Shortall, Shawn D Wettig
Aug 29, 2021·Pharmaceutics·José Antonio LebrónFrancisco J Ostos
Nov 19, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Abdullah O Ba-Salem, Jean Duhamel
Oct 12, 2020·Journal of Colloid and Interface Science·Catarina CostaEduardo F Marques

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Methods Mentioned

BETA
transfection
x-ray scattering
light
circular dichroism
dynamic light scattering

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