PMID: 7546632Jun 1, 1995Paper

Interactions between endothelial secretogogues

Annals of Medicine
R J Gryglewski

Abstract

Among endothelial secretogogues prostacyclin (PGI2), nitric oxide (NO) and tissue plasminogen activator (t-PA) play a crucial role in maintaining thromboresistance, tone and structure of the vascular wall. Most receptor agonists, such as B2 kinin receptor agonists, or shear force produce a coupled release of all three secretogogues, and therefore interactions between them are to be expected. Essentially, PGI2 is a platelet suppressant, NO a vasodilator and t-PA a fibrinolytic agent. These and other properties of endothelial secretogogues supplement each other in protecting the cardiovascular system from injuries. It is not surprising that disturbances of the secretory function of endothelial cells are associated with atherosclerosis, diabetes, thrombosis or hypertension. Traditionally, PGI2, NO, t-PA or their substitutes are used individually for the treatment of peripheral arterial disease, angina pectoris or acute myocardial infarction. In light of recent findings, their joint administration can be advocated. For instance, NO donors will potentiate platelet-suppressant action of PGI2 analogues, whereas exogenous PGI2 or TXA2 synthase inhibitors (i.e. following increase in endogenous PGI2) will abolish a paradox of prothrombot...Continue Reading

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Citations

Jul 11, 1996·European Journal of Pharmacology·R J GryglewskiJ Robak
Nov 2, 2004·Chemical & Pharmaceutical Bulletin·Li LiuHaijiang Zhang
Jul 31, 1998·European Journal of Pharmacology·J P De La CruzF Sánchez de la Cuesta
Nov 4, 2000·Expert Opinion on Investigational Drugs·M M Bednar
Apr 3, 1999·Stroke; a Journal of Cerebral Circulation·M M Bednar, C E Gross
Oct 23, 2001·American Journal of Physiology. Heart and Circulatory Physiology·C K NaberG Heusch

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