Interactions between gramicidin S and its producer, Bacillus brevis

Journal of Industrial Microbiology
T Azuma, A L Demain

Abstract

Gramicidin S (GS) inhibition of germination outgrowth of Bacillus brevis spores was reversed completely by a short pretreatment with sodium dodecyl sulfate, moderately by ethanol or by incubation at pH 10 but not by incubation at pH 4. Of five metal ions tested (Na+, Mg2+, Fe2+, Cu2+, Ca2+), only Ca2+ reversed GS inhibition. When Ca2+ (but not the other four metal ions) was added to the growth medium, there was a considerable portion of the biosynthesized GS found in the extracellular fluid. These findings are interpreted in terms of the binding of GS to the external layers of the B. brevis spore.

References

Jan 1, 1970·Journal of Bacteriology·L L MatzP Gerhardt
May 1, 1983·Journal of General Microbiology·J M Piret, A L Demain
Feb 1, 1960·Journal of General Microbiology·J A BERGER, A G MARR

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Citations

Mar 15, 2002·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·A L Demain, A Fang

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