PMID: 2094218Jan 1, 1990Paper

Interactions between group B streptococci and human cord blood lymphocytes

Biomedica Biochimica Acta
H J TietzW Mann

Abstract

Group B streptococci (Streptococcus agalactiae) of various serotypes (Ib/c, III/x, III/R, and B variant) and different sources of isolation were analyzed for their to interact with human mononuclear cells (MNC). Type I streptococci were obtained from a neonate dead of an invasive group B streptococcal infection. Examining the attachment of these bacteria to human peripheral lymphocytes and their ability to influence the proliferation of cultured adult and neonatal MNC, the following results were obtained: (1) Type Ib/c, III/x, and B variant strains adhered spontaneously to neonatal cord blood lymphocytes. The bacteria were bound by large lymphoid cells not detectable in the peripheral blood of adults. (2) Addition of group B streptococci to neonatal MNC cultures increased lymphocyte proliferation approximately 8 fold (n = 32) above the background. The reactivity of neonatal lymphocytes was highly reproducible with a mean peak proliferation close to day 5 of culture and a ratio of 60 CFU MNC. The control cell proliferation induced by Pokeweed mitogen (2 micrograms/ml) gave a mean stimulation index of 58. In contrast to cord blood cells, adult MNC responded only slightly with either proliferation of streptococcal binding. Clinica...Continue Reading

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