Interactions between growth hormone-releasing hormone and glucocorticoids in male rats

Regulatory Peptides
W B WehrenbergN Ling

Abstract

While chronic glucocorticoid treatment increases pituitary growth hormone (GH) content in rats and primates and increases pituitary GH release in response to growth hormone-releasing hormone (GHRH) in rats, it also inhibits somatic growth. We investigated these opposite actions in rats using the synthetic glucocorticoid dexamethasone. Seven days of dexamethasone treatment (40 micrograms/animal per day) did not alter the frequency of spontaneous GH pulses in conscious, freely-moving animals. The amplitude of the GH pulses in saline and dexamethasone-treated rats was different (P less than 0.01), the latter group having a higher incidence of GH levels less than 95 ng/ml, a lower incidence of GH levels between 96 and 251 ng/ml, and a higher incidence of GH values greater than 480 ng/ml. A 20 microgram/kg per day dose of dexamethasone was sufficient to significantly inhibit growth but was inadequate in enhancing the GH response to an acute injection of GHRH in anesthetized animals. These results support the concept that glucocorticoids exert their catabolic effects on somatic growth in peripheral tissues and not at the pituitary level.

References

Sep 2, 1976·The New England Journal of Medicine·J N Loeb
Jan 11, 1976·Endocrinology·H D Mosier, R A Jansons
Feb 1, 1985·The Journal of Clinical Endocrinology and Metabolism·K NakagawaM Kubo
Mar 1, 1985·Proceedings of the Society for Experimental Biology and Medicine·H D Mosier, R A Jansons
Oct 1, 1985·The Journal of Clinical Endocrinology and Metabolism·T G Unterman, L S Phillips
May 1, 1972·The Journal of Clinical Endocrinology and Metabolism·R DemuraK Miura
Jan 1, 1969·Acta Endocrinologica·G StrauchH Bricaire
Dec 9, 1968·Biochemical and Biophysical Research Communications·P O KohlerP L Rayford
Nov 1, 1968·Pediatric Research·M Winick, A Coscia
Jul 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·N LingR Guillemin
Aug 22, 1964·Lancet·M HARTOGR FRASER
Dec 31, 1964·The New England Journal of Medicine·A G FRANTZ, M T RABKIN

❮ Previous
Next ❯

Citations

May 1, 1993·Molecular and Cellular Endocrinology·J KononenM Pelto-Huikko
Oct 1, 1992·Trends in Endocrinology and Metabolism : TEM·A Giustina, W B Wehrenberg
Jan 17, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·K R KritschD M Ney
Jul 1, 1993·The Journal of Pediatric Endocrinology·M T Bluet-PajotC Kordon
Jan 1, 1994·Life Sciences·J H Thakore, T G Dinan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.