PMID: 2110197May 1, 1990Paper

Interactions between histamine and prostanoids in IgE-dependent, late cutaneous reactions in man

The Journal of Allergy and Clinical Immunology
R Grönneberg, S E Dahlén

Abstract

The contribution of histamine and cyclooxygenase metabolites of arachidonic acid to the wheal-and-flare reaction (WFR) (0 to 30 minutes) and the late cutaneous reaction (LCR) (1 to 24 hours) evoked by intradermal injection of antihuman IgE was appreciated in a comprehensive study of human volunteers treated with H1 and H2 antihistamines, cyclooxygenase inhibitors, as well as the combination of both types of drugs. The findings reinforce the concept that histamine is the major, but not exclusive, mediator of the WFR. In contrast, histamine accounted for but a limited portion of the LCR, but 48 hours of pretreatment with three different cyclooxygenase inhibitors, acetylsalicylic acid, indomethacin, or diclofenac sodium, had but a minor influence on the WFR, whereas all drugs produced a distinct overall inhibition of the LCR. However, for indomethacin, the inhibition was preceded by a potentiation (at 1 to 2 hours), which was abolished by antihistamines, suggesting increased histamine release from skin mast cells after cyclooxygenase inhibition. Furthermore, there was synergism between indomethacin and antihistamines during the LCR, and the combination of diclofenac sodium with antihistamines produced additive inhibition. It is pr...Continue Reading

References

Jan 1, 1977·Annual Review of Pharmacology and Toxicology·P Hedqvist
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J RaudP Hedqvist
May 1, 1989·The Journal of Clinical Investigation·E N CharlesworthL M Lichtenstein
Jun 1, 1989·The Journal of Allergy and Clinical Immunology·M E WeissN F Adkinson
Jan 1, 1985·Allergy·R Grönneberg, O Zetterström
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·S AbramsonG Weissmann
Jan 1, 1987·International Archives of Allergy and Applied Immunology·P VengeC G Peterson
Jan 1, 1973·The Journal of Allergy and Clinical Immunology·S P GalantH I Maibach
Jan 1, 1972·The Journal of Allergy and Clinical Immunology·J Dolovich, D C Little
Jan 1, 1982·Annual Review of Microbiology·M K Bach
Oct 1, 1982·The Journal of Allergy and Clinical Immunology·W DorschR Geiger
Jan 1, 1981·Annual Review of Pharmacology and Toxicology·J C Foreman
Apr 1, 1984·The Journal of Clinical Investigation·R A Lewis, K F Austen
Jan 1, 1957·International Archives of Allergy and Applied Immunology·G B WEST

❮ Previous
Next ❯

Citations

Jul 1, 1996·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·T OhtsukaM Arita
Feb 1, 1992·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M JohnsonC J Whelan
Feb 1, 1992·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R Grönneberg, O Zetterström
May 1, 1993·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·W A MasseyL M Lichtenstein
May 1, 1991·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R Grönneberg, O Zetterström

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Related Papers

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
R Grönneberg, O Zetterström
Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
G J Gleich
© 2021 Meta ULC. All rights reserved