Interactions between hormones and epilepsy

Seizure : the Journal of the British Epilepsy Association
Erik TaubøllSigrid Svalheim

Abstract

There is a complex, bidirectional interdependence between sex steroid hormones and epilepsy; hormones affect seizures, while seizures affect hormones thereby disturbing reproductive endocrine function. Both female and male sex steroid hormones influence brain excitability. For the female sex steroid hormones, progesterone and its metabolites are anticonvulsant, while estrogens are mainly proconvulsant. The monthly fluctuations in hormone levels of estrogen and progesterone are the basis for catamenial epilepsy described elsewhere in this issue. Androgens are mainly anticonvulsant, but the effects are more varied, probably because of its metabolism to, among others, estradiol. The mechanisms for the effects of sex steroid hormones on brain excitability are related to both classical, intracellularly mediated effects, and non-classical membrane effects due to binding to membrane receptors. The latter are considered the most important in relation to epilepsy. The different sex steroids can also be further metabolized within the brain to different neurosteroids, which are even more potent with regard to their effect on excitability. Estrogens potentiate glutamate responses, primarily by potentiating NMDA receptor activity, but also ...Continue Reading

References

Mar 1, 1992·Archives of Neurology·A G Herzog
Jun 1, 1988·Neuroendocrinology·L H O'ConnorB S McEwen
Jun 1, 1987·Brain Research Bulletin·S S SmithD J Woodward
Apr 15, 1985·Brain Research·F Nicoletti, J L Meek
Mar 1, 1987·British Journal of Pharmacology·G A CottrellJ A Peters
May 13, 1998·Epilepsia·D M FeeneyW Gilmore
Oct 21, 1999·Epilepsia·H E EdwardsN J MacLusky
Nov 26, 2002·Annals of Neurology·Martha J MorrellMark V Sauer
Jun 7, 2003·Epilepsy & Behavior : E&B·Amee D BairdDavid C Reutens
Aug 6, 2003·Epilepsy & Behavior : E&B·Andrew G HerzogDonald L Schomer
May 1, 1959·Neurology·J LOGOTHETISF TORRES
Nov 5, 2003·Annals of Neurology·Andrew G HerzogDonald L Schomer
Jan 16, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Csaba LeranthNeil J MacLusky
Sep 24, 2004·Cleveland Clinic Journal of Medicine·Sheryl S Smith, Catherine S Woolley
Nov 14, 2006·Epilepsy & Behavior : E&B·Eeva LöfgrenJouko I T Isojärvi
Dec 25, 2007·Seizure : the Journal of the British Epilepsy Association·Erik TaubøllLeif Gjerstad
Dec 29, 2007·Seizure : the Journal of the British Epilepsy Association·Eva Hellmis
Jan 1, 2008·Seizure : the Journal of the British Epilepsy Association·Jouko Isojärvi
Jan 1, 2008·Seizure : the Journal of the British Epilepsy Association·Cynthia L Harden
Jan 1, 2008·Seizure : the Journal of the British Epilepsy Association·Andrew G Herzog
Sep 3, 2008·Neuropharmacology·Alastair M HosieTrevor G Smart

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Citations

Mar 12, 2016·Progress in Neurobiology·Hanshu ZhaoZhongling Zhang
Sep 29, 2015·Neural Plasticity·Valentina LicheriEnrico Sanna
May 18, 2016·Current Treatment Options in Neurology·Allison Navis, Cynthia Harden
May 3, 2018·Biology of Reproduction·Cecilie Hurup MunkboelBjarne Styrishave
May 28, 2019·The Journal of Headache and Pain·Angela KoverechPaolo Martelletti
May 5, 2020·Journal of the American Veterinary Medical Association·Claudia KabakchievHugues Beaufrère
Jul 17, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hyun-Kyoung LimMinah Suh
Nov 22, 2016·Journal of Neuroscience Research·Doodipala Samba Reddy
Aug 5, 2017·Epilepsia·Emily L Johnson, Peter W Kaplan
Jun 6, 2018·Biology of Sex Differences·Yanyan MaoYuelian Sun
May 6, 2020·Proceedings of the National Academy of Sciences of the United States of America·Gabrielle M SchroederYujiang Wang
Sep 5, 2019·British Journal of Biomedical Science·C RawatR Kukreti
May 30, 2020·Brain Communications·Shimian QuRobert L Macdonald
Aug 6, 2019·Epilepsy & Behavior : E&B·Daniel Pérez-PérezLuisa Rocha
Sep 29, 2020·BMJ Paediatrics Open·Cary FuTimothy Benke
Sep 30, 2020·The Journal of Steroid Biochemistry and Molecular Biology·Malene Louise JohannsenBjarne Styrishave
May 15, 2021·Neurology and Therapy·Mervyn J Eadie
Jun 26, 2021·Seizure : the Journal of the British Epilepsy Association·Gonçalo VideiraJoão Chaves
Sep 11, 2018·Seizure : the Journal of the British Epilepsy Association·Barbara MostacciPaolo Tinuper

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