Interactions between irradiated and unirradiated tissues during supernumerary limb formation in the newt

The Journal of Experimental Zoology
N HolderP W Tank

Abstract

The interactions between irradiated and unirradiated blastemas and stumps in the newt forelimb were studied. Irradiated right blastemas at the stage of early digits were grafted to unirradiated left stumps and unirradiated left blastemas were grafted to irradiated right stumps. Grafts were oriented with their anterior-posterior axes opposed to that of the stumps. Supernumerary limbs ranging in completeness from one to four digits were found to arise predominantly on the anterior or posterior sides of the host limb. The graft developed well when the blastema was unirradiated and had reversed handedness with respect to the stump. Irradiated grafts developed poorly. On occasions, limbs with two supernumerary structures were found. The results are discussed in terms of the origin of the cells which comprise the supernumerary limbs and their bearing on a recently presented model concerned with pattern specification and regulation in epimorphic fields.

References

May 18, 1978·Nature·M Maden, R N Turner
Jul 1, 1976·The Journal of Experimental Zoology·M Maden, H Wallace
Sep 10, 1976·Science·V FrenchS V Bryant
Jan 1, 1971·Current Topics in Developmental Biology·L Wolpert
Mar 1, 1974·Wilhelm Roux' Archiv Für Entwicklungsmechanik Der Organismen·Susan V Bryant, Laurie E Iten
Dec 1, 1973·Wilhelm Roux' Archiv Für Entwicklungsmechanik Der Organismen·Laurie E Iten, Susan V Bryant

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Citations

Feb 1, 1980·Developmental Biology·N HolderS V Bryant
Sep 1, 1984·Developmental Biology·K Muneoka, S V Bryant
Jul 1, 1992·Developmental Biology·S V Bryant, D M Gardiner
Feb 1, 1989·Developmental Biology·S K SessionsS V Bryant
Feb 4, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·David L Stocum, Jo Ann Cameron
Jun 19, 2016·Developmental Biology·Catherine D McCuskerDavid M Gardiner
Feb 1, 1988·Clinical and Experimental Pharmacology & Physiology·G K MoldenhauerT O Morgan

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