Interactions Between KIR3DS1 and HLA-F Activate Natural Killer Cells to Control HCV Replication in Cell Culture

Gastroenterology
Sebastian LunemannMarcus Altfeld

Abstract

Killer-cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer (NK) cells. Binding of KIR3DS1 to its recently discovered ligand, HLA-F, activates NK cells and has been associated with resolution of hepatitis C virus (HCV) infection. We investigated the mechanisms by which KIR3DS1 contributes to the antiviral immune response. Using cell culture systems, mice with humanized livers, and primary liver tissue from HCV-infected individuals, we found that the KIR3DS1 ligand HLA-F is up-regulated on HCV-infected cells, and that interactions between KIR3DS1 and HLA-F contribute to NK cell-mediated control of HCV. Strategies to promote interaction between KIR3DS1 and HLA-F might be developed for treatment of infectious diseases and cancer.

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Citations

Nov 2, 2018·HLA : Immune Response Genetics·Matthew D BluntSalim I Khakoo
Dec 21, 2018·Immunology·Leidy Y Bastidas-Legarda, Salim I Khakoo
Nov 23, 2019·International Journal of Immunogenetics·Matthew D Blunt, Salim I Khakoo
Apr 25, 2019·International Journal of Molecular Sciences·Franziska M WürfelWolfgang Würfel
Jun 25, 2019·Frontiers in Immunology·Glòria MartrusMarcus Altfeld
Nov 14, 2019·International Journal of Molecular Sciences·Gia-Gia T HòChristina Bade-Doeding
Apr 10, 2020·Journal of Clinical Medicine·Gaitan Fabrice NjiomegnieGolo Ahlenstiel
May 28, 2019·Frontiers in Immunology·Aifen Lin, Wei-Hua Yan
May 1, 2021·The Journal of Infectious Diseases·Enrique BernalAlfredo Minguela
Jun 11, 2021·International Journal of Immunogenetics·Christine NeuchelJoannis Mytilineos
Jun 26, 2021·Cell·Shira Weingarten-GabbayPardis C Sabeti
Jul 8, 2021·Seminars in Immunopathology·A J HightonM Altfeld
Sep 18, 2021·Science Immunology·Johannes M JungMadeleine J Bunders

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