Interactions between LTP- and LTD-inducing stimulation in the sensorimotor cortex of the awake freely moving rat

Journal of Neurophysiology
David J Froc, Ronald J Racine

Abstract

Bidirectional modifications in synaptic efficacy are central components in models of cortical learning and memory. More recently, the regulation of synaptic plasticity according to the history of synaptic activation, termed "metaplasticity," has become a focus of research on the physiology of memory. Here we explore such interactions between long-term potentiation (LTP) and long-term depression (LTD) in the chronically prepared rat. The effects of successive high- and low-frequency stimulation were examined in sensorimotor cortex in the adult, freely moving rat. High-frequency (300 Hz) stimulation (HFS) applied to the white matter was used to induce LTP, and prolonged, low-frequency (1 Hz) stimulation (LFS) was used to induce either depotentiation or LTD. Combined stimulation (HFS/LFS or LFS/HFS) during the induction phase attenuated potentiation effects only if the LFS followed the HFS. LTD induced by LFS alone was expressed as a reduction in the amplitude of both short- and long-latency field potential components, whereas depotentiation was primarily expressed as a decrease in the amplitude of the potentiated long-latency component. In other experiments, LTP (or LTD) was induced to asymptotic levels before applying LFS (or HF...Continue Reading

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Citations

Jan 22, 2011·Journal of Neural Engineering·James M Rebesco, Lee E Miller
Sep 4, 2008·Journal of Integrative Neuroscience·Bruce G Mockett, Sarah R Hulme
Aug 4, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Matthew O HebbIvar Mendez
Aug 2, 2006·Reviews in the Neurosciences·Bernardo Moreno-López, David González-Forero
Jan 1, 2015·Nature Reviews. Disease Primers·Stephen T HolgatePeter D Sly
Jan 12, 2016·The European Journal of Neuroscience·Chanel J TaylorWickliffe C Abraham
Jul 31, 2020·ELife·Tuomo Mäki-MarttunenKim T Blackwell
Feb 20, 2021·European Journal of Pharmacology·Zi-Fan MaiChu-Hua Li
Nov 21, 2009·Epilepsy & Behavior : E&B·Sridhar SunderamMarom Bikson

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