PMID: 6972997May 1, 1981Paper

Interactions between lymphocyte membrane molecules. I. Interaction between B lymphocyte surface IgM and Fc IgG receptors requires ligand occupancy of both receptors

The Journal of Experimental Medicine
H B Dickler, M T Kubicek

Abstract

The independent B lymphocyte surface membrane receptors IgM and Fc IgG receptors were evaluated for interactions using immunoflourescence. Ligand [F(ab')2 anti-mu]-induced capping of surface IgM resulted in capping of Fc IgG receptors only if the latter were occupied during the capping process by: (a) soluble antigen-antibody complexes that themselves provided insufficient cross-linking to result in capping; or (b) monomeric IgG at physiologic concentrations (or less) either purified or as normal serum. Ligand-induced capping of Fc IgG receptors did not result in capping of surface IgM occupied by monomeric F(ab') anti-mu. Control experiments showed that ligand binding to or capping of only one of these two receptors has no effect on the other, and that there were no cross-reactions. The interaction appears specific in that ligand-induced capping of surface IgM did not induce capping of ligand-occupied surface IgD or I-A antigens. Thus, there appears to be a specific interaction between ligand-bound surface IgM and ligand-bound Fc IgG receptors on the B lymphocyte surface. The results also indicate that binding of monomeric IgG produces a reversible alteration in the Fc IgG receptor leading to association with ligand-bound surf...Continue Reading

References

Jan 1, 1976·Scandinavian Journal of Immunology·P H Krammer, B Pernis
Apr 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·L Flaherty, D Zimmerman
Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·P DragstenJ Schlessinger
Jan 1, 1979·Scandinavian Journal of Immunology·R J Klingenstein, H B Dickler
Mar 1, 1978·The Journal of Experimental Medicine·D G SieckmannW E Paul
Oct 1, 1979·The Journal of Experimental Medicine·L FlahertyS S Wachtel
Jul 1, 1976·The Journal of Experimental Medicine·H B DicklerD H Sachs
Oct 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·P CuatrecasasC B Anfinsen
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Jan 1, 1980·Immunological Reviews·M K Hoffmann
Jul 1, 1963·Proceedings of the Society for Experimental Biology and Medicine·G WIEDERMANNE C FRANKLIN

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Citations

Jan 1, 1984·Folia Microbiologica·L Fornůsek, V Vĕtvicka
Jan 1, 1986·Immunologic Research·M G Goodman, R L Wolfert
Apr 1, 1993·Immunological Reviews·E BaixerasC Martínez
Feb 1, 1992·Immunological Reviews·W H FridmanC Sautes

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