Interactions between lysyl oxidases and ADAMTS proteins suggest a novel crosstalk between two extracellular matrix families

Matrix Biology : Journal of the International Society for Matrix Biology
Rohtem AviramPeleg Hasson

Abstract

The extracellular matrix (ECM) regulates numerous cellular events in addition to providing structural integrity. Among several protein and enzyme families implicated in functions of the ECM, the lysyl oxidases and ADAMTS proteins are known to participate in microfibril and elastic fiber formation as well as ECM-associated signaling. A yeast two-hybrid screen to identify lysyl oxidase (LOX) binding proteins identified ADAMTSL4 as a potential interactor. We demonstrate here that several members of the LOX and ADAMTS families interact with one another. Upon investigating the interaction between LOX and ADAMTSL2 we found that the absence or inhibition of Lox affected ADAMTSL2 molecular forms and reduced its tissue levels. Thus, ADAMTSL2 stability and inter-molecular complexes may depend on the activity of lysyl oxidases.

Citations

Jul 19, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Xiaoke Yin 殷晓科Manuel Mayr
Sep 7, 2019·Essays in Biochemistry·Sylvain D Vallet, Sylvie Ricard-Blum
Jan 11, 2020·Frontiers in Cell and Developmental Biology·Katiúcia Batista Silva PaivaAriadne Letra
Dec 29, 2020·American Journal of Medical Genetics. Part a·Jacob SteinleMerlin G Butler
Nov 24, 2019·Matrix Biology : Journal of the International Society for Matrix Biology·Claudia Umana-DiazLaurent Muller
Jun 11, 2020·Seminars in Cell & Developmental Biology·Françoise Helmbacher, Sigmar Stricker

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