Interactions between metallothionein inducers in rat liver and primary cultures of rat hepatocytes

Chemico-biological Interactions
J HernandezJ Hidalgo

Abstract

The interaction of Zn, stress and endotoxin on liver metallothionein (MT) regulation has been studied in the rat. Zn, stress and endotoxin increased liver MT levels significantly, by 12-, 5- and 8-fold, respectively. The previous administration of Zn to stress or endotoxin treatments increased MT levels by 35- and 42-fold, respectively, indicating a synergistic effect in both cases. In contrast, when liver MT was preinduced by stress, MT levels were further increased by endotoxin only in an additive manner. In another experiment where liver MT induction by stress was studied in control rats and in rats with preinduced MT by Zn, endotoxin or stress, it was found that Zn pretreated animals had higher MT-I mRNA levels than endotoxin- or stress-pretreated ones. No synergisms between dexamethasone, Zn, TNF and IFN were observed in primary culture of hepatocytes. These results suggest that the observed synergisms between Zn and other MT inducers in vivo in the liver is a consequence of increased Zn levels in the body and mobilization capacity, with concomitant MT synthesis.

References

May 1, 1992·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J HidalgoJ S Garvey
Apr 1, 1992·Toxicology and Applied Pharmacology·K S MinK Tanaka
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·J ZengJ H Kägi
Jun 15, 1991·Toxicology and Applied Pharmacology·J LiuC D Klassen
Jan 1, 1990·Annual Review of Nutrition·I Bremner, J H Beattie
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J J Schroeder, R J Cousins
Jan 1, 1987·Annual Review of Biochemistry·S PestkaC E Samuel
Apr 1, 1989·British Medical Bulletin·F R Balkwill
Jan 1, 1988·Toxicology and Applied Pharmacology·L D Lehman-McKeemanC D Klaassen
Jan 1, 1988·Toxicology and Applied Pharmacology·L D Lehman-McKeemanC D Klaassen
Jan 1, 1986·Annual Review of Biochemistry·D H Hamer
Feb 1, 1985·Molecular and Cellular Biology·M K Yagle, R D Palmiter
Jan 1, 1984·Methods in Enzymology·J S Garvey, M F Heil
Feb 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·D M DurnamR D Palmiter
May 1, 1984·The Biochemical Journal·S R Quinones, R J Cousins

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