PMID: 8968175Dec 1, 1996Paper

Interactions between midazolam and remifentanil during monitored anesthesia care

Anesthesiology
M N AvramovP F White

Abstract

Remifentanil, an ultra-short-acting opioid analgesic, may be useful as an intravenous adjuvant to local anesthesia for treating patient discomfort and pain during monitored anesthesia care (MAC). However, the remifentanil dose requirements, interactions with other commonly used sedative drugs (such as midazolam), and recovery characteristics after ambulatory procedures have not been determined. Therefore, this study was designed to evaluate the safety and efficacy of remifentanil alone and in combination with different doses of midazolam during MAC. Eighty-one healthy consenting women scheduled for elective breast biopsy procedures were randomly assigned to one of four treatment groups according to an institutional review board-approved, double-blind, placebo-controlled protocol. The study medication (containing either saline or 2 mg, 4 mg, or 8 mg of midazolam) was administered intravenously 5 min before starting an infusion of remifentanil at 0.1 microgram.kg-1.min-1. The remifentanil infusion was subsequently adjusted in 0.025- and 0.05-microgram.kg-1.min-1 increments to maintain patient comfort and adequate ventilation during the operation. The level of sedation was assessed at 1- to 10-min intervals during the procedure us...Continue Reading

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Citations

Dec 13, 2002·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Franco CavaliereRodolfo Proietti
Mar 21, 2013·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Kevin D Johnston, Mridula R Rai
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