Interactions between mivacurium, rocuronium, and vecuronium during general anesthesia

Anesthesia and Analgesia
D W KimE R Johnson

Abstract

This study was designed to examine the interactions between mivacurium and rocuronium or vecuronium when administered during a standardized anesthetic technique. Seventy healthy women undergoing abdominal hysterectomy procedures with a standardized thiopental-sufentanil-desflurane-nitrous oxide anesthetic technique were randomly assigned to one of seven treatment groups (10 patients each). After a tracheal intubating dose of vecuronium 100 micrograms/kg (Groups 1 and 2), rocuronium 600 micrograms/kg (Groups 3 and 4), or mivacurium 250 micrograms/kg (Groups 5, 6, and 7), patients received vecuronium, 25 micrograms/kg (Groups 1 and 6), rocuronium 150 micrograms/kg (Groups 3 and 7), or mivacurium 50 micrograms/kg (Groups 2, 4, and 5) for maintenance of neuromuscular blockade. Neuromuscular function was assessed using electromyography, with a train-of-four mode of stimulation at the wrist every 10 s. The clinical duration (time for T1 to return to 25% of baseline) of the maintenance dose of mivacurium was significantly longer after an intubating dose of rocuronium (40 +/- 8 min) and vecuronium (28 +/- 6 min) than after mivacurium (12 +/- 3 min). The clinical duration of maintenance doses of vecuronium (18 +/- 6 min) and rocuronium ...Continue Reading

References

Jan 1, 1992·Journal of Clinical Anesthesia·A F Ghouri, P F White
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Citations

Oct 30, 1998·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·J FinstererP Sporn
Apr 13, 2005·European Journal of Clinical Pharmacology·C MotamedP Duvaldestin
Dec 17, 1997·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·S SchiereJ M Wierda
Nov 22, 2002·European Journal of Anaesthesiology·S M Sator-KatzenschlagerC Weinstabl
Feb 1, 2006·Clinical and Experimental Pharmacology & Physiology·Alejandro A Nava-OcampoJorge Salmerón

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