PMID: 6980420Apr 1, 1982Paper

Interactions between molecules (subfactors) released by different T cell sets that yield a complete factor with biological (suppressive) activity

Proceedings of the National Academy of Sciences of the United States of America
W PtakR K Gershon

Abstract

T cells that have been immunized to express optimal levels of contact hypersensitivity upon adoptive transfer to normal animals can be inhibited from doing so by incubating them with an antigen-specific T suppressor factor. This factor is composed of at least two subunits which come from cells expressing different Ly phenotypes; an antigen-specific antigen-binding "subfactor" is made by an Ly-1 cell and a non-antigen-binding one is made by an Ly-2 cell. Neither of these cells nor their products express detectable amounts of major histocompatibility gene products. The mode of immunization plays an important role in determining which of these subfactors will be produced. Painting the skin with a reactive hapten immunizes Ly-1 cells that secrete antigen-binding material, whereas intravenous injection of trinitrobenzenesulfonic acid activates Ly-2 cells to produce a second subunit that does not see antigen. There is reason to believe that the molecule that does not bind to antigen does have some antigen specificity. An analysis of the data at hand suggests that the antigen specificity stems from an interaction of the two subunits described with yet another subunit and that biological activity is dependent upon three macromolecules....Continue Reading

References

Aug 1, 1978·The Journal of Experimental Medicine·W PtakR K Gershon
Sep 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·R W RosensteinR K Gershon
Jan 1, 1980·Immunological Reviews·H N ClamanJ W Moorhead
Jan 1, 1980·Immunological Reviews·G L AshersonM A Perera
May 1, 1980·Springer Seminars in Immunopathology·R N Germain, B Benacerraf
Jan 1, 1980·Immunological Reviews·M I Greene, B Benacerraf

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Citations

Dec 1, 1987·Immunology Letters·P M FloodW Ptak
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·B RyffelE Huberman
Apr 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·W Ptak, R K Gershon
Apr 1, 1984·The Journal of Experimental Medicine·M TaniguchiM Kanno
Feb 19, 2015·Archivum Immunologiae Et Therapiae Experimentalis·Włodzimierz PtakKrzysztof Bryniarski
Apr 1, 1985·Immunological Reviews·M Taniguchi, T Sumida
Apr 1, 1988·International Reviews of Immunology·R E ConeD R Green
Jun 1, 1989·Journal of Surgical Oncology·A M EijánS Oisgold-Dagá

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