Interactions between NO and O2 in the microcirculation: a mathematical analysis

Microvascular Research
Kathleen A Lamkin-KennardDov Jaron

Abstract

Biotransport of nitric oxide (NO) and of oxygen (O(2)) in the microcirculation are inherently interdependent, since all nitric oxide synthase (NOS) isoforms (eNOS, nNOS, and iNOS) require O(2) to produce NO. Furthermore, tissue O(2) consumption is reversibly inhibited by NO. To investigate these complex interactions, a mathematical model was developed for coupled mass transport of NO and O(2) around a cylindrical arteriole using finite element computational methods. Steady-state radial NO and O(2) gradients in the bloodstream, plasma layer, endothelium, vascular wall, and surrounding tissue were simulated for different conditions. Special cases of the model were solved, including O(2)-dependent NO production from eNOS alone, and with additional NO production from either nNOS or iNOS at specified locations. The model predicts that (a) concentration changes in one species can have significant effects on transport of the other species with the degree of interaction dependent on spatial gradients; (b) eNOS NO production rates required to maintain the concentration of NO in the vascular wall are more dependent on NO scavenging in blood than in tissue; (c) relatively low rates of NO production in tissue from either nNOS or iNOS can e...Continue Reading

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Citations

Aug 10, 2006·Journal of Mathematical Biology·Wensheng Zhang, Aurélie Edwards
Jan 20, 2007·Annals of Biomedical Engineering·Xuewen ChenDov Jaron
Mar 25, 2011·Medical & Biological Engineering & Computing·Xuewen ChenDov Jaron
Aug 17, 2006·Antioxidants & Redox Signaling·Mahendra Kavdia
May 19, 2007·Antioxidants & Redox Signaling·Donald G Buerk
Mar 12, 2008·Antioxidants & Redox Signaling·Kejing ChenAleksander S Popel
Jun 22, 2010·Antioxidants & Redox Signaling·Krishna SriramDaniel M Tartakovsky
Aug 28, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Krishna SriramDaniel M Tartakovsky
Apr 17, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Krishna SriramMarcos Intaglietta
Dec 27, 2011·Critical Reviews in Biomedical Engineering·Donald G BuerkDov Jaron
Feb 5, 2008·Free Radical Biology & Medicine·Xiaojun HeDaniel B Kim-Shapiro
Sep 22, 2010·Nitric Oxide : Biology and Chemistry·Melanie P Chin, William M Deen
Mar 26, 2009·Biophysical Chemistry·Sharon Irene GundersenAndre Francis Palmer
May 27, 2008·Nitric Oxide : Biology and Chemistry·Melanie P ChinWilliam M Deen
Apr 29, 2008·Free Radical Biology & Medicine·Douglas D ThomasDavid A Wink
Apr 28, 2011·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·C Makena HightowerMarcos Intaglietta
Nov 19, 2013·Journal of Cellular and Molecular Medicine·Elizabeth A LogsdonFeilim Mac Gabhann
Nov 23, 2007·Biophysical Journal·Xiaoping LiuAvner Friedman
Dec 1, 2005·Microvascular Research·Nina VukosavljevicDonald G Buerk
Dec 14, 2011·Microvascular Research·Peng Kai OngSangho Kim
Jul 16, 2009·Nitric Oxide : Biology and Chemistry·Catherine N Hall, John Garthwaite
Jul 15, 2016·Biophysical Journal·Krishna SriramDaniel M Tartakovsky
Dec 9, 2009·Free Radical Biology & Medicine·Xiaoping LiuJay L Zweier
May 29, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Yan Cheng NgSangho Kim
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Sep 13, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Mahendra Kavdia, Aleksander S Popel
Jul 28, 2020·PLoS Computational Biology·William Davis HaseldenPatrick J Drew
Jun 10, 2018·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Yien LiuDov Jaron
Jul 16, 2021·PLoS Biology·Qingguang ZhangPatrick J Drew

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