Interactions between paraoxonase 1 genetic polymorphisms and smoking and their effects on oxidative stress and lung cancer risk in a Korean population

PloS One
Sang-Yong EomHeon Kim

Abstract

Few studies in epidemiology have evaluated the effects of gene-environment interaction on oxidative stress, even though this interaction is an important etiologic factor in lung carcinogenesis. We investigated the effects of the genetic polymorphisms of paraoxonase 1 (PON1), smoking, and the interaction between the two on lung cancer risk and oxidative stress. This study's subjects consisted of 416 newly diagnosed lung cancer patients and an equal number of matched controls. The GoldenGate assay was used for genotypic analyses of the PON1 gene. Urinary 8-hydroxydeoxyguanosine (8-OHdG) and thiobarbituric acid reactive substances levels were measured as indicators of oxidative stress. The PON1 rs662 AA genotype showed a significantly lower risk of lung cancer than the GG genotype (OR = 0.60, 95% CI: 0.36-0.99). The protective effect of the PON1 rs662 AA genotype on lung cancer risk was limited to non-smokers. Lung cancer patients who had the rs662 A allele showed a dose-dependent association between smoking status and oxidative stress markers. Among non-smoking lung cancer patients, urinary 8-OHdG levels were significantly lower in individuals with the rs662 GA and AA genotypes than in those with the GG genotype. Furthermore, we ...Continue Reading

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Citations

May 30, 2020·International Journal of Molecular Sciences·Melanie GrailleNancy B Hopf
Jul 16, 2020·Revista gaúcha de enfermagem·Christiane BreyDario Consonni
Feb 16, 2021·Acta Odontologica Scandinavica·Ingrede Tatiane Serafim SantanaFelipe Rodrigues de Matos
Oct 8, 2021·The Science of the Total Environment·Rong ZhongJianbo Tian

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Methods Mentioned

BETA
genotyping
enzyme-linked immunosorbent assay

Software Mentioned

SAS
Genetic Power Calculator
Haploview

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