Interactions between peripheral blood CD8 T lymphocytes and intestinal epithelial cells (iEC)

Clinical and Experimental Immunology
F A ArosaD N Posnett

Abstract

Intestinal intraepithelial lymphocytes (iIEL) are primarily CD8 cells and most of them have a CD28- phenotype, the phenotype of effector cytotoxic T cells. We asked whether the predominance of CD8+CD28- T cells in the gut may result from peripheral blood T cells preferentially migrating to the iIEL compartment and adhering to iEC. Compared with CD4 cells, adhesion of resting CD8+ T cells to iEC cell lines was significantly higher. Adhesion could be blocked with a MoAb to gp180, a molecule expressed on iEC which is known to interact with CD8/lck. No significant difference in the level of adhesion was observed between CD8+CD28+ and CD8+CD28- T cells. Thus CD8 cells may preferentially migrate to the iIEL compartment, but loss of CD28 expression could occur in situ after migration. Consistent with this hypothesis, the CD8+CD28- cells became enriched after co-culturing T cells with iEC cell lines and primary iEC. Induction of the CD8+CD28- phenotype in cord blood and adult T cells was observed in co-cultures with iEC and also with mitogens and superantigens. In the latter case, CD28 down-modulation was seen specifically in the Vbeta subset targeted by the superantigen, indicating that loss of CD28 expression is a direct result of T ...Continue Reading

References

Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·B RochaD Guy-Grand
Jan 1, 1992·The Journal of Experimental Medicine·C Van KerckhoveM B Brenner
Jan 1, 1989·European Journal of Immunology·R Testi, L L Lanier
Sep 1, 1987·European Journal of Immunology·N Cerf-BensussanC Griscelli
Sep 1, 1993·The Journal of Experimental Medicine·A PanjaL Mayer
Feb 1, 1995·Scandinavian Journal of Immunology·G BollJ Reimann
Oct 1, 1994·The Journal of Experimental Medicine·G G GrossS P Balk
Jul 1, 1994·European Journal of Immunology·M LattheT T MacDonald
Sep 1, 1993·Gastroenterology·L QiaoS C Meuer
Mar 1, 1994·International Immunology·C GouttefangeasA Bensussan
Dec 1, 1993·Clinical and Experimental Immunology·A I RobertsE C Ebert
Jan 1, 1996·Scandinavian Journal of Immunology·W O DutraD G Colley
Feb 15, 1996·Transplantation·K KawaiP S Ohashi
Feb 1, 1996·The American Journal of Physiology·D M McKayM H Perdue
Jun 1, 1997·Clinical and Experimental Immunology·Z X LiuT Toyota
Nov 14, 1997·The Journal of Experimental Medicine·D HamannR A van Lier

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Citations

Mar 1, 2002·Immunology and Cell Biology·Fernando A Arosa
Jul 27, 2001·Clinical and Experimental Immunology·M C AldhousS Ghosh
Feb 28, 2016·Archivum Immunologiae Et Therapiae Experimentalis·Anna Korecka-PolakGrażyna Korczak-Kowalska
May 8, 2000·Alcoholism, Clinical and Experimental Research·F A ArosaM de Sousa
May 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Margareta P CorreiaFernando A Arosa
Jan 18, 2017·Frontiers in Immunology·Fernando A ArosaElsa M Cardoso
Mar 9, 2017·Frontiers in Immunology·Elsa M Cardoso, Fernando A Arosa

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