PMID: 22579002May 15, 2012Paper

Interactions between phytochemical components of Sutherlandia frutescens and the antiretroviral, atazanavir in vitro: implications for absorption and metabolism

Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society for Pharmaceutical Sciences, Société Canadienne Des Sciences Pharmaceutiques
Adrienne C MüllerIsadore Kanfer

Abstract

African traditional medicinal plants, such as Sutherlandia frutescens have the potential to interact pharmacokinetically with the protease inhibitor class of antiretrovirals, thereby impacting on their safety and efficacy. The effects of extracts and phytochemical components of Sutherlandia frutescens, on the in vitro absorption and metabolism of the protease inhibitor, atazanavir were thus investigated. Aqueous and methanolic extracts of Sutherlandia frutescens were prepared by freeze-drying of hot water and methanol decoctions of Sutherlandia frutescens plant material respectively, whilst crude triterpenoid glycoside and flavonol glycoside fractions were isolated by solvent extraction and subsequent column chromatography. Atazanavir was quantitated in the absence or presence of these compounds as well as commercially available purported constituents of Sutherlandia frutescens, namely, L-canavanine, L-GABA and D-pinitol, after a one hour co-incubation in Caco-2 cell monolayers and human liver microsomes. The triterpenoid and flavonol glycoside fractions were found to be present in the aqueous and methanolic extracts of Sutherlandia frutescens and were shown to contain the sutherlandiosides and sutherlandins known to be present...Continue Reading

Citations

Jan 15, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Adrienne C MüllerIsadore Kanfer
May 17, 2014·Expert Opinion on Drug Metabolism & Toxicology·Carlemi CalitzJosias H Hamman
Jul 11, 2013·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Oluwaseyi M AboyadeGail Hughes
Aug 28, 2015·European Journal of Drug Metabolism and Pharmacokinetics·Enoche F OgaToshiharu Horie
Dec 6, 2018·Nutrients·Agnieszka Owczarczyk-SaczonekBogusław Buszewski
Dec 5, 2012·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Pius S FasinuBernd Rosenkranz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Glycosides

Cardiac glycosides are a diverse family of naturally derived compounds that bind to and inhibit na+/k+-atpase. Discover the latest research on cardiac glycosides heres.