Interactions between polyphenolic antioxidants quercetin and naringenin dictate the distinctive redox-related chemical and biological behaviour of their mixtures.

Scientific Reports
Monika BaranowskaAgnieszka Bartoszek

Abstract

Food synergy concept is suggested to explain observations that isolated antioxidants are less bioactive than real foods containing them. However, mechanisms behind this discrepancy were hardly studied. Here, we demonstrate the profound impact of interactions between two common food flavonoids (individual: aglycones quercetin-Q and naringenin-N- or their glycosides rutin-R and naringin-N+ vs. mixed: QN- and RN+) on their electrochemical properties and redox-related bioactivities. N- and N+ seemed weak antioxidants individually, yet in both chemical and cellular tests (DPPH and CAA, respectively), they increased reducing activity of mixtures synergistically. In-depth measurements (differential pulse voltammetry) pointed to kinetics of oxidation reaction as decisive factor for antioxidant power. In cellular (HT29 cells) tests, the mixtures exhibited properties of a new substance rather than those of components. Pure flavonoids did not influence proliferation; mixtures stimulated cell growth. Individual flavonoids tended to decrease global DNA methylation with growing concentration; this effect was more pronounced for mixtures, but not concentration-dependent. In nutrigenomic studies, expression of gene set affected by QN- differed...Continue Reading

References

Dec 1, 1995·The American Journal of Clinical Nutrition·P C HollmanM B Katan
Jun 29, 2000·Journal of Hypertension·N S DhallaT Netticadan
Apr 17, 2001·Biochemical and Biophysical Research Communications·A Sekher PannalaC A Rice-Evans
Sep 25, 2004·Protein Science : a Publication of the Protein Society·Timothy A HinsleyMay Tassabehji
Nov 13, 2004·Annals of Internal Medicine·Edgar R MillerEliseo Guallar
Jul 23, 2005·Molecular Pharmacology·Won Jun LeeBao Ting Zhu
Oct 27, 2005·Journal of Agricultural and Food Chemistry·Emma RamiroMargarida Castell
Jan 25, 2006·Chemico-biological Interactions·M ValkoM Mazur
Dec 22, 2006·The Journal of Nutrition·Mingzhu FangChung S Yang
Mar 17, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jean-Pierre J Issa
Oct 2, 2007·Journal of Agricultural and Food Chemistry·Kelly L Wolfe, Rui Hai Liu
Aug 6, 2008·Journal of Agricultural and Food Chemistry·María Angeles MartínLuis Goya
Dec 2, 2008·European Journal of Nutrition·Emma Ramiro-PuigMargarida Castell
Dec 31, 2009·Phytotherapy Research : PTR·María Angeles MartínLuis Goya
Feb 17, 2010·Analytical Biochemistry·Johannes F WentzelPieter J Pretorius
Jul 4, 2012·International Journal of Molecular Sciences·Laura De MartinoVincenzo De Feo
Mar 19, 2013·International Journal of Molecular Sciences·Branislav Ruttkay-NedeckyRene Kizek
Nov 12, 2013·Antioxidants & Redox Signaling·Khader AwwadIngrid Fleming
May 23, 2014·Current Biology : CB·Michael Schieber, Navdeep S Chandel
Dec 19, 2014·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Alessio PerottiAnnamaria Buschini
Mar 17, 2015·Free Radical Biology & Medicine·Geoffroy WalbrecqBernard Knoops
Apr 30, 2017·Experimental & Molecular Medicine·Jungeun AnMyunggon Ko
Feb 10, 2018·Nature Communications·Emilia MiraSantos Mañes
May 16, 2018·The Journal of Pharmacy and Pharmacology·Clément ChaletPatrick Augustijns
Oct 13, 2018·Scientific Reports·Qinlian HouDeguan Li
May 14, 2019·BioMed Research International·Cinzia ForniRavirajsinh N Jadeja
Jan 9, 2020·Biological Chemistry·Kazuyoshi Yamauchi, Yasushi Kawakami

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Citations

Nov 30, 2021·Journal of Asian Natural Products Research·Yan-Bin RenJin-Hui Wang

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