PMID: 1204612Nov 1, 1975Paper

Interactions between prostaglandin analogues and a receptor in bovine Corpora lutea. Correlation of dissociation constants with luteolytic potencies in hamsters

European Journal of Biochemistry
W S PowellJ Jarabak

Abstract

The dissociation constants for the interactions between some prostaglandin analogues and a prostaglandin F2 receptor in bovine corpora lutea were determined. These values were compared to the antifertility potencies of these compounds in hamsters and the rates of metabolism by 15-hydro-syprostaglandin dehydrogenase. The most active analogues with regard to both affinity for the receptor and luteolytic potency were 17-phenyl-18, 19, 20-trinorprostaglandin F2alpha and 15-methylprostaglandin F2alpha. The alkyl side chain of prostaglandins could be modified considerably without altering the affinity for the receptor. In this way metabolism by 15-hydroxyprostaglandin dehydrogenase could be blocked. Some of these compounds -ad greatly increased luteolytic effects. Substitution of a phenyl group for the 3 terminal carbon units of the alkyl side chain of prostaglandins increased both the affinity for the receptor and the luteolytic activity in vivo. 7-oxa-13-prostynoic acid, an antagonist of the luteolytic effect of prostaglandin F2alpha in vivo was a weak competitive inhibitor of the interation between prostaglandin F2alpha and the receptor.

References

Aug 1, 1975·European Journal of Biochemistry·W S PowellB Samuelsson
Jan 1, 1975·Prostaglandins·B J MagerleinG A Youngdale
Jun 1, 1974·Lancet·W S PowellB Sjöberg
Jan 1, 1972·Annual Review of Pharmacology·J R Weeks
Sep 4, 1974·Journal of the American Chemical Society·E W YankeeG L Bundy
Mar 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·J Jarabak
Aug 2, 1972·Nature: New Biology·J A McCrackenB Samuelsson
May 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·G F Cooper, J Fried
Jul 1, 1973·Prostaglandins·B J MagerleinJ R Weeks
Jan 3, 1974·European Journal of Biochemistry·W S PowellB Samuelsson
May 10, 1974·Prostaglandins·G A Youngdale, F H Lincoln
Mar 22, 1972·Journal of the American Chemical Society·G L BundyJ E Pike
Oct 1, 1969·European Journal of Biochemistry·E Granström, B Samuelsson
Jan 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·B B Pharriss, L J Wyngarden
Mar 29, 1969·Nature·P W RamwellN Andersen

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Citations

Nov 1, 1976·Molecular and Cellular Endocrinology·C V Rao
Aug 27, 1999·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·T L Davis, N A Sharif
Aug 1, 1980·European Journal of Biochemistry·U Kyldén, S Hammarström
Mar 1, 1977·Prostaglandins·F A Kimball, L J Wyngarden
Feb 6, 2008·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Maria Elisa Rodrigues CoimbraPaulo Guilherme Coelho
Dec 20, 2002·The Journal of Pharmacology and Experimental Therapeutics·Guillaume MonneretWilliam S Powell
Oct 17, 2006·The Journal of Pharmacology and Experimental Therapeutics·Chantal CossetteWilliam S Powell
Dec 1, 1983·Asia-Oceania Journal of Obstetrics and Gynaecology·S TanakaM Hashimoto
Apr 1, 1982·Archives of Biochemistry and Biophysics·S Hammarström

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