PMID: 16515031Mar 7, 2006Paper

Interactions between radiation and hormonal therapy in breast cancer: simultaneous or sequential treatment

Orvosi hetilap
János Fodor

Abstract

Combining radiation and hormone therapy (administration of selective estrogen receptor modulators) has become common clinical practice in recent years for receptor positive breast cancer. Little is known about a possible interaction of both treatment modalities if they are given simultaneously. Tamoxifen (antiestrogen molecule, triphenylethylene derivative) may theoretically render cancer cells less responsive to radiotherapy arresting hormone-receptor-positive cells in G0/G1 phase and increase the risk of breast and lung fibrosis stimulating the secretion of transforming growth factor beta in human fibroblasts. This article reviews the published data to assess the impact of sequencing of hormonal and radiation therapy on outcomes in breast cancer. Computerised searches for publications debating the sequencing of hormonal therapy relative to radiation therapy were done using MEDLINE data. Results of tamoxifen experiments with cell culture regarding radioprotection of tumour clonogens are conflicting. In contrast to in vitro results, in animal studies no protective effect of tamoxifen was observed. In one in vitro study, letrozole (non-steroid selective aromatase inhibitor) had a radiosensitizing effect on breast-cancer lines. N...Continue Reading

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