PMID: 8943739Oct 1, 1996Paper

Interactions between renal tubules and interstitium

Journal of Clinical Pathology
Alexander J Howie, C J Lote

Abstract

Renal tubules and interstitium have close physiological associations. Changes in both are often seen in renal disease. Damaged tubules can attract inflammatory cells and stimulate interstitial fibrosis, but do not always do so. Interstitial inflammation can damage tubules and can also stimulate fibrosis, and is probably always initiated by tubular events. Interstitial and tubular abnormalities are closely associated with changes in renal excretory function, but tubular events are more important. A main determinant of the outcome of renal disease is whether tubules can recover, not the extent of interstitial changes. If tubules are atrophic, they will not recover and renal function will be permanently impaired.

References

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Mar 1, 1990·The Journal of Pathology·A J HowieJ Sparke
May 1, 1989·Kidney International·E G Neilson
Jun 1, 1995·Scandinavian Journal of Urology and Nephrology·G PapanikolaouA J Howie
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Aug 1, 1993·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·A J Howie
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Dec 1, 1995·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·A J HowieA D Barnes
Feb 1, 1996·Kidney International·J Egido

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Citations

May 2, 2008·American Journal of Physiology. Renal Physiology·Lisa M CurtisPaul W Sanders
Oct 29, 2004·International Journal of Urology : Official Journal of the Japanese Urological Association·Masaki MuramatsuAkira Hasegawa
Aug 31, 2016·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Sokho KimJungkee Kwon

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