Interactions between SH2 and SH3 domains

Biochemical and Biophysical Research Communications
M Vihinen, C I Smith

Abstract

Src homology 2 (SH2) and SH3 domains are abundant protein and peptide binding modules in signalling molecules. Certain SH2 and SH3 domains have been shown to form functional and physical interactions. The structural basis of dimer formation was studied by docking three dimensional structures of the domains and by analysing structural and functional properties of the dimers. The experimentally verified dimers were noticed to have very large buried surfaces, extensive hydrogen bonding networks, and complementary surfaces, properties which are characteristic for protein-protein interactions. The number of hydrogen bonds between the domains is exceptionally high for interacting protein pairs. Also the buried accessible surface is large, especially when considering the small size of the domains. The dimer results were used to describe mutation information in structural terms and to discuss regulation of protein tyrosine kinases.

References

Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·R R RousselA P Laudano
Jan 25, 1991·Cell·L C CantleyS Soltoff
Jun 1, 1990·Molecular and Cellular Biology·M C O'BrienH Hanafusa
Nov 5, 1988·Journal of Molecular Biology·J JaninC Chothia
Jul 1, 1988·Protein Engineering·P Argos
Dec 15, 1994·Biochemical and Biophysical Research Communications·M VihinenC I Smith
Feb 16, 1995·Nature·T Pawson
Apr 11, 1995·Proceedings of the National Academy of Sciences of the United States of America·K AlexandropoulosD Baltimore
Mar 12, 1993·Cell·Z SongyangR J Lechleider
Apr 14, 1995·Science·S MaignanA Ducruix
Jan 27, 1995·Cell·G B CohenD Baltimore
Aug 16, 1994·Proceedings of the National Academy of Sciences of the United States of America·G ChengD Baltimore
Jan 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·S Jones, J M Thornton
Jan 19, 1996·The Journal of Biological Chemistry·D H NgP Johnson
Oct 4, 1996·The Journal of Biological Chemistry·C CoutureT Mustelin
Feb 13, 1997·Nature·F SicheriJ Kuriyan
May 29, 1997·Biochemical and Biophysical Research Communications·M RojasY Z Lin
Sep 5, 1997·The Journal of Biological Chemistry·M Y KanemitsuW Eckhart

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Citations

Mar 7, 2001·Molecular Biology and Evolution·M Nars, M Vihinen
Mar 6, 2002·Biopolymers·Michael P Okoh, Mauno Vihinen
Jun 1, 2011·The Journal of Cell Biology·Junya HasegawaToshiki Itoh
Jun 10, 2000·Molecular and Cellular Biology·F R Cross, M D Jacobson
Nov 17, 2009·Immunological Reviews·Konstantin NeumannJürgen Wienands
Feb 22, 2002·European Journal of Biochemistry·Alan ChengMichel L Tremblay
Mar 1, 2000·Biochemical and Biophysical Research Communications·I LappalainenM Vihinen

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