Interactions between stressful environment and gene deletions alleviate the expected average loss of fitness in yeast.

Genetics
Lukasz JasnosRyszard Korona

Abstract

The conjecture that the deleterious effects of mutations are amplified by stress or interaction with one another remains unsatisfactorily tested. It is now possible to reapproach this problem systematically by using genomic collections of mutants and applying stress-inducing conditions with a well-recognized impact on metabolism. We measured the maximum growth rate of single- and double-gene deletion strains of yeast in several stress-inducing treatments, including poor nutrients, elevated temperature, high salinity, and the addition of caffeine. The negative impact of deletions on the maximum growth rate was relatively smaller in stressful than in favorable conditions. In both benign and harsh environments, double-deletion strains grew on average slightly faster than expected from a multiplicative model of interaction between single growth effects, indicating positive epistasis for the rate of growth. This translates to even higher positive epistasis for fitness defined as the number of progeny. We conclude that the negative impact of metabolic disturbances, regardless of whether they are of environmental or genetic origin, is absolutely and relatively highest when growth is fastest. The effect of further damages tends to be w...Continue Reading

References

Jan 1, 1989·Annual Review of Genetics·A A Pakula, R T Sauer
Dec 1, 1966·Genetical Research·W G Hill, A Robertson
Sep 1, 1995·Microbiological Reviews·W H Mager, A J De Kruijff
Apr 1, 1995·Genetical Research·N H Barton
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·S A ShabalinaA S Kondrashov
Sep 27, 2000·Evolution; International Journal of Organic Evolution·L L VassilievaM Lynch
Feb 7, 2001·Proceedings of the National Academy of Sciences of the United States of America·K SzafraniecR Korona
Apr 23, 2002·Nature Reviews. Genetics·Sarah P Otto, Thomas Lenormand
Jun 1, 2002·Microbiology and Molecular Biology Reviews : MMBR·Stefan Hohmann
Jun 21, 2002·Methods in Enzymology·Fred Sherman
Jul 26, 2002·Nature·Guri GiaeverMark Johnston
May 31, 2003·Journal of Biology·Roy Kishony, Stanislas Leibler
Feb 7, 2004·Science·Amy Hin Yan TongCharles Boone
Apr 10, 2004·Nature Genetics·Susanna K Remold, Richard E Lenski
Jul 9, 2004·Genome Biology·Bart Scherens, Andre Goffeau
Dec 14, 2004·Nature Genetics·Daniel SegrèRoy Kishony
Feb 12, 2005·Proceedings. Biological Sciences·Tim F CooperSantiago F Elena
May 7, 2005·Nature Biotechnology·Ryan Kelley, Trey Ideker
Jun 10, 2005·Microbiology and Molecular Biology Reviews : MMBR·David E Levin
Sep 13, 2005·Nature Genetics·Armaity P DavierwalaTimothy R Hughes
Nov 29, 2005·Trends in Genetics : TIG·Siew Loon OoiJef D Boeke
Mar 21, 2006·Genetics·Roger D KouyosSebastian Bonhoeffer
Jan 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J F Crow, M Kimura
Aug 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·M W FeldmanL D Brooks
Jul 25, 2006·Genome Biology·Sean R CollinsJonathan S Weissman
Dec 16, 2006·Nature Reviews. Microbiology·Yong-Sun BahnMaria E Cardenas
Jan 19, 2007·Nature Reviews. Genetics·J Arjan G M de Visser, Santiago F Elena
Dec 1, 1966·Genetics·M Kimura, T Maruyama
Feb 1, 2007·Evolution; International Journal of Organic Evolution·Guillaume Martin, Thomas Lenormand
Feb 27, 2007·Nature Genetics·Lukasz Jasnos, Ryszard Korona
Mar 6, 2007·Trends in Ecology & Evolution·Roger D KouyosSebastian Bonhoeffer

❮ Previous
Next ❯

Citations

Feb 5, 2010·Proceedings. Biological Sciences·Graham Bell
Oct 7, 2011·Proceedings. Biological Sciences·J Arjan G M de VisserSantiago F Elena
Mar 14, 2012·PloS One·Agata Jakubowska, Ryszard Korona
May 1, 2012·Genetics·Alison M Wardlaw, Aneil F Agrawal
Aug 13, 2013·Genetics·James J BullIan J Molineux
Jul 12, 2013·The Journal of Physical Chemistry. B·Ivan A RazinkovJeff Hasty
Nov 12, 2013·Evolution; International Journal of Organic Evolution·Alethea D WangAneil F Agrawal
Nov 26, 2010·Current Opinion in Biotechnology·Anders Blomberg
Jun 12, 2010·Trends in Ecology & Evolution·Aneil F Agrawal, Michael C Whitlock
Dec 15, 2015·Journal of Evolutionary Biology·S A KraemerN Colegrave
Aug 22, 2009·Journal of Evolutionary Biology·Jadene A YoungAneil F Agrawal
Dec 5, 2012·Evolution; International Journal of Organic Evolution·Sandra TrindadeIsabel Gordo
Nov 17, 2015·Scientific Reports·Sonja LehtinenChristine Orengo
Apr 25, 2015·Evolution; International Journal of Organic Evolution·Guillaume Martin, Thomas Lenormand
Jan 28, 2015·PloS One·Brandon BarkerZhenglong Gu
Sep 9, 2017·Evolution; International Journal of Organic Evolution·Susanne A KraemerNick Colegrave
Jul 7, 2018·Journal of Evolutionary Biology·Devin Arbuthnott, Michael C Whitlock

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.