Interactions between tacrolimus and antimicrobial agents

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
D L Paterson, N Singh

Abstract

Tacrolimus is being increasingly used as an immunosuppressive agent in transplant recipients. The drug is metabolized by the cytochrome P-450 3A system, thus antimicrobials that inhibit or induce these enzymes can alter levels of tacrolimus in the bloodstream. Tacrolimus is potentially nephrotoxic and neurotoxic; the likelihood of toxicity rises as blood levels of the drug increase. Increased tacrolimus levels and subsequent toxicity have been produced by a number of antimicrobial agents that inhibit the cytochrome P-450 3A system. Conversely, drugs with the potential to induce the cytochrome P-450 3A system can reduce the levels of tacrolimus in the blood, leading to increased risk of acute rejection in transplant recipients. Antimicrobial agents that can have adverse effects on renal function may add to the nephrotoxicity of tacrolimus. The potential for drug interactions should be reviewed before antimicrobial agents are prescribed to patients treated with tacrolimus.

Citations

May 29, 2013·International Journal of Pharmaceutics·Noël KnopsDirk Kuypers
Feb 27, 1999·Journal of Clinical Pharmacy and Therapeutics·E Tanaka
May 18, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P SellierJ Passeron
Nov 1, 2003·Surgical Infections·Jennifer A HagertyCosme Manzarbeitia
Apr 9, 1999·Medicine·D L Paterson, N Singh
Feb 14, 2007·Transplantation·Lluis CastellsCarlos Margarit
Oct 22, 2008·Nutrition & Metabolism·Zakia Bibi
Aug 23, 2002·Clinical Pharmacokinetics·Uwe ChristiansAlfonso Lampen
Aug 2, 2015·Lancet·Burke A CunhaEmilio Bouza
Nov 21, 2015·Expert Review of Clinical Immunology·Joseph R ScaleaKenneth L Brayman
Oct 13, 2005·Expert Opinion on Pharmacotherapy·Paul O Gubbins, Jarrett R Amsden
Jul 16, 2004·Kidney International·Hassane IzzedineGilbert Deray
Feb 4, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Santiago MorenoAdolfo Martínez
Oct 29, 2011·Neurologic Clinics·Rajat Dhar, Theresa Human
Oct 27, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Jun 16, 2011·British Journal of Clinical Pharmacology·Chaitali PasseyPamala A Jacobson
Sep 17, 2013·Transplant Infectious Disease : an Official Journal of the Transplantation Society·I W TingC C Huang
Jan 21, 2012·Transplant Infectious Disease : an Official Journal of the Transplantation Society·K Y PolatS Emre
Aug 13, 2009·Transplant Infectious Disease : an Official Journal of the Transplantation Society·A P GarrisonA I Hartstein
Jul 26, 2005·The Annals of Thoracic Surgery·Torsten BossertFriedrich W Mohr
Apr 9, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Y MeijeUNKNOWN ESCMID Study Group of Infection in Compromised Hosts
Sep 1, 2015·The Medical Clinics of North America·Christopher J Wong, Genevieve Pagalilauan
Nov 27, 2014·Frontiers in Oncology·Khalid Ahmed Al-AnaziWaleed Khalid Al-Anazi
Sep 7, 2016·Case Reports in Transplantation·Naomi HauserTodd Roberts
Oct 5, 2016·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Thaís Felli KubiçaSydney Hartz Alves
Mar 25, 2006·Expert Opinion on Pharmacotherapy·Kasra Shakeri-Nejad, Ralf Stahlmann
Jan 20, 2005·Circulation·Robert L PageJoAnn Lindenfeld
Sep 22, 2005·Therapeutic Drug Monitoring·Eva M VasquezEnrico Benedetti
Oct 28, 2019·European Journal of Clinical Pharmacology·Takaya UnoMitsutaka Takada
Sep 27, 2018·European Journal of Clinical Pharmacology·Takaya UnoMitsutaka Takada
Jul 30, 2020·Expert Opinion on Drug Metabolism & Toxicology·Alexandra L DegraeveLaure Elens
Nov 17, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Sonia SolomonNicole Hayde
Mar 1, 2019·Canadian Journal of Kidney Health and Disease·Rachel JeongNgan N Lam
Mar 4, 2021·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Bercemhan YazirliMustafa Arici
Mar 21, 2021·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Mohammad M RabieiIlad Alavi Darazam
May 25, 2021·Seminars in Respiratory and Critical Care Medicine·Daniel Z P Friedman, Karen Doucette
May 25, 2021·Medical Mycology Case Reports·Julien GrasJean-Michel Molina

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Related Papers

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Stefania CocchiGiovanni Guaraldi
Pediatric Infectious Disease
J E Springate
Australian and New Zealand Journal of Medicine
N ScanlonJ Kolbe
© 2021 Meta ULC. All rights reserved