PMID: 7546833Jan 1, 1995Paper

Interactions between the immune system and breast cancer

Acta Oncologica
H M OgmundsdóttirI Gudmundsdóttir

Abstract

The functional and prognostic significance of lymphocytic infiltration of breast carcinomas has remained unclear. Using primary cultures we have demonstrated that lymphocytes could stimulate the growth of breast cancer epithelium in about half of the cases tested. The growth stimulation was subsequently shown to be strongly correlated with expression of MHC class I by the tumour cells. Furthermore, preliminary data suggest that carcinomas with a mixed population of MHC class I-positive and -negative cells were associated with a higher incidence of lymph node metastases and increased relapse rate compared with tumours that were homogeneously MHC class I-positive or -negative. The interactions between breast cancer and the immune system are clearly complex and the results suggest that the nature of these interactions can be some extent be determined by the level and pattern of MHC class I expression by the tumour cells.

References

Nov 1, 1990·Scandinavian Journal of Immunology·P B Júlíusson, H M Ogmundsdóttir
Dec 1, 1993·In Vitro Cellular & Developmental Biology. Animal·H M OgmundsdóttirO W Petersen

❮ Previous
Next ❯

Citations

Dec 5, 2000·International Journal of Cancer. Journal International Du Cancer·I GudmundsdóttirH M Ogmundsdóttir
May 7, 1999·International Journal of Immunopharmacology·J W Hadden
Nov 3, 2015·Biochemical and Biophysical Research Communications·Shankar SumanYogeshwer Shukla
Aug 8, 1998·The Journal of Surgical Research·P Y WongD P Braun
Jan 7, 2004·Nature Reviews. Cancer·Jeffrey W Pollard
Oct 11, 2001·Cancer Gene Therapy·J O OjeifoJ A Zwiebel
Sep 1, 2017·IUBMB Life·Xiaohui WangXiangyang Xie
Apr 11, 2006·Molecular Cancer Research : MCR·Haitian LuChuanshu Huang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.