PMID: 9194067May 1, 1997Paper

Interactions between the serotoninergic and noradrenergic systems of the brain and their role in the regulation of animal behavior

Neuroscience and Behavioral Physiology
T P Semenova, M K Tiku

Abstract

Studies were carried out using DBA/2 mice on the relationship between the behavioral effects of antagonists of different types of 5-HT receptors and the level of activity of alpha 2-adrenoceptors. The 5-HT1c receptor antagonists mianserin (2 mg/kg) and cyproheptadine (2 mg/kg) and the 5-HT2 receptor antagonist ketanserin (3 mg/kg) had no effect on movement activity, while the 5-HT3 and 5-HT4 receptor antagonists zacopride (1 mg/kg) and ICS 205-930 (1 mg/kg) reduced movement behavior in intact animals. On a background of treatment with the alpha 2-adrenoceptor blocker yohimbine (0.5 mg/kg), mianserin, cyproheptadine, and ketanserin inhibited movement activity and significantly reduced the sensitivity of animals to audiogenic convulsions. These data indicate that administration of alpha 2-adrenoceptor antagonists increases the efficiency with which serotonin receptors regulate behavior.

References

May 1, 1988·British Journal of Pharmacology·G A Kennett, G Curzon

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Citations

Jan 7, 2010·Journal of Neural Transmission·Norbert GyongyosiGyorgy Bagdy
Jul 9, 2002·Hippocampus·Hiroshi TakahashiAkikazu Takada
Oct 25, 2011·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Tayfun I Uzbay
Nov 16, 2013·Experimental Brain Research·Mohammad Hadi GharedaghiReza Rahimian

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