Interactions between the tachykinins and calcitonin gene-related peptide lead to the modulation of oedema formation and blood flow in rat skin.

British Journal of Pharmacology
S D Brain, T J Williams

Abstract

1. The mechanisms involved in tachykinin-induced oedema were investigated in rat skin and interactions between the tachykinins and calcitonin gene-related peptide (CGRP) were studied. 2. Intradermal injections of the tachykinins, substance P, neurokinin A and neurokinin B, stimulated local oedema formation which was in each case potentiated by co-injection of the vasodilator CGRP. Oedema induced by substance P, in the presence and absence of CGRP, was significantly inhibited by pretreatment of rats with a combination of the histamine H1 antagonist, mepyramine, and the 5-hydroxytryptamine antagonist, methysergide. Oedema induced by neurokinin A or B was not inhibited by this pretreatment. 3. Intradermally-injected CGRP induced a long lasting increase in local blood flow, which was measured with a laser Doppler blood flow meter. The simultaneous injection of substance P, but not of the structurally-related neurokinins, caused a loss of the prolonged vasodilator activity of CGRP. 4. These results show that oedema induced by substance P is partially dependent on mast cell amines and that only substance P causes a loss of the prolonged vasodilator activity of CGRP. 5. We suggest that the ability of substance P to prevent the persist...Continue Reading

References

Dec 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·F Lembeck, P Holzer
Dec 8, 1977·Nature·T J Williams, M J Peck
Jul 1, 1977·European Journal of Pharmacology·L A Chahl
Sep 1, 1977·The Journal of Investigative Dermatology·G A Holloway, D W Watkins
Sep 24, 1985·European Journal of Pharmacology·P Le GrevesT Hökfelt
Jan 1, 1986·The British Journal of Dermatology·W Piotrowski, J C Foreman
Oct 1, 1986·The Journal of Investigative Dermatology·S D BrainT J Williams
Dec 1, 1987·British Journal of Pharmacology·R W FullerP J Barnes
Jan 3, 1985·Nature·S D BrainI MacIntyre
Jul 21, 1971·Nature: New Biology·M M ChangH D Niall
Jul 29, 1983·Biochemical and Biophysical Research Communications·K KangawaH Matsuo

❮ Previous
Next ❯

Citations

Jan 1, 1993·Agents and Actions·R Mathison, J S Davison
Dec 4, 1990·European Journal of Pharmacology·S R HughesS D Brain
Mar 7, 1996·European Journal of Pharmacology·M MorishitaS Torii
Jan 1, 1992·Peptides·P PersicoR Porta
May 1, 1993·General Pharmacology·J Donnerer, R Amann
Sep 1, 1993·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·R MathisonA D Befus
Aug 15, 1997·Regulatory Peptides·L O CardellJ A Nadel
Mar 25, 1998·Neurotoxicology and Teratology·P CarrilloP Pacheco
Jul 28, 2012·Nature Neuroscience·Isaac M ChiuClifford J Woolf
Jan 30, 2002·British Journal of Pharmacology·Andrew D GrantSusan D Brain
Jan 11, 2003·British Journal of Pharmacology·Masahiro NagahamaJun Sakurai
Apr 3, 1998·Respirology : Official Journal of the Asian Pacific Society of Respirology·M L KowalskiM A Kaliner
May 1, 1991·British Journal of Pharmacology·F Y Lam, W R Ferrell
Mar 1, 1993·British Journal of Pharmacology·F Y Lam, W R Ferrell
Mar 1, 1993·British Journal of Pharmacology·P Newbold, S D Brain
Mar 1, 1995·British Journal of Pharmacology·M M Campos, J B Calixto
Oct 1, 1995·British Journal of Pharmacology·A AhluwaliaC A Maggi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.