Abstract
Chagas disease, which ranks among the world's most neglected diseases, is a chronic, systemic, parasitic infection caused by the protozoan Trypanosoma cruzi. Mepraia species are the wild vectors of this parasite in Chile. Host-parasite interactions can occur at several levels, such as co-speciation and ecological host fitting, among others. Thus, we are exploring the interactions between T. cruzi circulating in naturally infected Mepraia species in all areas endemic of Chile. We evaluated T. cruzi infection rates of 27 different haplotypes of the wild Mepraia species and identified their parasite genotypes using minicircle PCR amplification and hybridization tests with genotype-specific DNA probes. Infection rates were lower in northern Chile where Mepraia gajardoi circulates (10-35%); in central Chile, Mepraia spinolai is most abundant, and infection rates varied in space and time (0-55%). T. cruzi discrete typing units (DTUs) TcI, TcII, TcV, and Tc VI were detected. Mixed infections with two or more DTUs are frequently found in highly infected insects. T. cruzi DTUs have distinct, but not exclusive, ecological and epidemiological associations with their hosts. T. cruzi infection rates of M. spinolai were higher than in M. gaj...Continue Reading
References
Oct 1, 1988·Revista de saúde pública·A Perlowagora-SzumlewiczC J Moreira
Jan 1, 1984·Transactions of the Royal Society of Tropical Medicine and Hygiene·M A MilesC J Schofield
May 1, 1984·The Journal of protozoology·M P DeaneC M Morel
Mar 1, 1982·The American Journal of Tropical Medicine and Hygiene·E S Garcia, J A Dvorak
Dec 1, 1994·The American Journal of Tropical Medicine and Hygiene·P WinckerC M Morel
Mar 1, 1996·Experimental Parasitology·C B MelloN A Ratcliffe
Mar 21, 1998·International Journal for Parasitology·M Tibayrenc
Mar 9, 2000·Acta Tropica·L F FerreiraA Araújo
Mar 7, 2001·Acta Tropica·C BarnabéM Tibayrenc
Feb 10, 2004·Proceedings of the National Academy of Sciences of the United States of America·Arthur C AufderheideMarvin Allison
Jan 11, 2005·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·D A UrreaG A Vallejo
Mar 22, 2007·Acta Tropica·Catarina A C AraújoAna M Jansen
Oct 2, 2007·Acta Tropica·Ricardo CamposAldo Solari
Jun 27, 2008·Acta Tropica·Catarina A C AraújoAna M Jansen
Oct 28, 2008·Experimental Parasitology·Ana María Mejía-JaramilloOmar Triana-Chávez
Nov 11, 2008·Acta Tropica·G A VallejoG A Schaub
Oct 10, 2009·The American Journal of Tropical Medicine and Hygiene·Ximena CoronadoAldo Solari
Jan 12, 2010·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·M R CortezF Noireau
Aug 31, 2010·Trends in Parasitology·Eloi S GarciaGünter A Schaub
Sep 30, 2010·Neotropical Entomology·Daniel Frías-Lasserre
Oct 6, 2010·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Fernando Torres-PérezPedro E Cattan
Aug 11, 2011·PLoS Neglected Tropical Diseases·Carlos A Flores-López, Carlos A Machado
Oct 25, 2011·PLoS Neglected Tropical Diseases·Michael D LewisMichael A Miles
Oct 26, 2011·Vector Borne and Zoonotic Diseases·Marco ArenasAldo Solari
May 9, 2012·PLoS Neglected Tropical Diseases·Fabio Faria da MotaPatricia Azambuja
Dec 4, 2012·Vector Borne and Zoonotic Diseases·R CamposA Solari
Dec 20, 2012·The American Journal of Tropical Medicine and Hygiene·Andrea ToledoAldo Solari
May 15, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Ricardo CamposAldo Solari
Mar 7, 2014·Parasites & Vectors·Catarina A C AraújoAna M Jansen
Mar 29, 2014·International Journal for Parasitology·Felipe GuhlJuan David Ramírez
Apr 2, 2014·Parasites & Vectors·Silvia Andrade JustiCleber Galvão
Jun 18, 2014·The American Journal of Tropical Medicine and Hygiene·Camila EgañaAldo Solari
Jun 19, 2015·Acta Tropica·Carezza Botto-MahanAldo Solari
Citations
Oct 23, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Ricardo Campos-SotoCarezza Botto-Mahan
Jun 6, 2019·Memórias do Instituto Oswaldo Cruz·José C BáezIván C Suazo-Galdames
Jun 12, 2020·PloS One·Ricardo Campos-SotoFernando Torres-Pérez
Oct 23, 2020·PeerJ·Ricardo Campos-SotoFernando Torres-Pérez
Jun 8, 2021·Research and Reports in Tropical Medicine·Günter A Schaub