Interactions between vascular endothelial growth factor and neuroglobin.

Neuroscience Letters
Kunlin JinDavid A Greenberg

Abstract

Vascular endothelial growth factor (VEGF) and neuroglobin (Ngb) participate in neuronal responses to hypoxia and ischemia, but the relationship between their effects, if any, is unknown. To address this issue, we measured Ngb levels in VEGF-treated mouse cerebrocortical cultures and VEGF levels in cerebrocortical cultures from Ngb-overexpressing transgenic mice. VEGF stimulated Ngb expression in a VEGFR2/Flk1 receptor-dependent manner, whereas Ngb overexpression suppressed expression of VEGF. These findings provide further insight into hypoxia-stimulated neuronal signaling pathways.

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Citations

Apr 23, 2014·IUBMB Life·Paolo AscenziMaria Marino
Jan 30, 2013·Biochimica Et Biophysica Acta·Marco FiocchettiMaria Marino
Sep 28, 2016·Frontiers in Neurology·Eliana BaezGeorge E Barreto
Nov 9, 2016·Molecular Aspects of Medicine·Paolo AscenziMaria Marino
Nov 4, 2016·International Journal of Molecular Sciences·Diego GuidolinLuigi F Agnati
Mar 19, 2020·Cells·Emilie PicardFrancine Behar-Cohen
Nov 6, 2014·Biomolecular Concepts·Xin Yao Qiu, Xiao Qian Chen
Jul 10, 2018·Molecular Neurobiology·Ricardo CabezasGeorge E Barreto
Jul 30, 2019·Oxidative Medicine and Cellular Longevity·Marco FiocchettiMaria Marino
Mar 7, 2021·Archives of Biochemistry and Biophysics·Marco FiocchettiMaria Marino

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