Interactions between Vitamin D Status, Calcium Intake and Parathyroid Hormone Concentrations in Healthy White-Skinned Pregnant Women at Northern Latitude

Nutrients
Andrea HemmingwayMairead E Kiely

Abstract

Adverse effects of low vitamin D status and calcium intakes in pregnancy may be mediated through functional effects on the calcium metabolic system. Little explored in pregnancy, we aimed to examine the relative importance of serum 25-hydroxyvitamin D (25(OH)D) and calcium intake on parathyroid hormone (PTH) concentrations in healthy white-skinned pregnant women. This cross-sectional analysis included 142 participants (14 ± 2 weeks' gestation) at baseline of a vitamin D intervention trial at 51.9 °N. Serum 25(OH)D, PTH, and albumin-corrected calcium were quantified biochemically. Total vitamin D and calcium intakes (diet and supplements) were estimated using a validated food frequency questionnaire. The mean ± SD vitamin D intake was 10.7 ± 5.2 μg/day. With a mean ± SD serum 25(OH)D of 54.9 ± 22.6 nmol/L, 44% of women were <50 nmol/L and 13% <30 nmol/L. Calcium intakes (mean ± SD) were 1182 ± 488 mg/day and 23% of participants consumed <800 mg/day. The mean ± SD serum albumin-adjusted calcium was 2.2 ± 0.1 mmol/L and geometric mean (95% CI) PTH was 9.2 (8.4, 10.2) pg/mL. PTH was inversely correlated with serum 25(OH)D (r = -0.311, p < 0.001), but not with calcium intake or serum calcium (r = -0.087 and 0.057, respectively, both...Continue Reading

References

Nov 10, 2005·JAMA : the Journal of the American Medical Association·Laufey SteingrimsdottirGunnar Sigurdsson
Oct 27, 2007·The Proceedings of the Nutrition Society·Ann Prentice
Dec 5, 2008·Nutrition Reviews·Ann Prentice
Dec 10, 2008·The American Journal of Clinical Nutrition·Kevin D CashmanMairead Kiely
Mar 20, 2009·The American Journal of Clinical Nutrition·Kevin D CashmanMairead Kiely
Jun 18, 2010·The American Journal of Clinical Nutrition·Landing M A JarjouAnn Prentice
Aug 6, 2010·The Journal of Clinical Endocrinology and Metabolism·John F AloiaHenian Chen
Sep 18, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·O M GutiérrezE N Taylor
Jan 5, 2011·International Journal of Endocrinology·Stuart A HamiltonCarol L Wagner
Jun 8, 2011·The Journal of Clinical Endocrinology and Metabolism·Michael F HolickUNKNOWN Endocrine Society
Jul 16, 2011·Annual Review of Nutrition·Patsy M Brannon, Mary Frances Picciano
Oct 5, 2011·Nutrition Reviews·Hala Ahmadieh, Asma Arabi
Apr 12, 2012·The American Journal of Clinical Nutrition·Bridget E YoungKimberly O O'Brien
Aug 3, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·U K MøllerL Rejnmark
Nov 22, 2012·The British Journal of Nutrition·Paul HaggartyAlan M Wallace
May 31, 2013·The American Journal of Clinical Nutrition·Mona S Calvo, Jaime Uribarri
Jul 26, 2013·The American Journal of Clinical Nutrition·Theresa O SchollT Peter Stein
Aug 6, 2013·Nutrients·Sara CastiglioniJeanette A M Maier
Feb 7, 2014·The American Journal of Clinical Nutrition·Theresa O SchollT Peter Stein
Feb 15, 2014·Physiologia Plantarum·Edward J M JoyMartin R Broadley
Mar 14, 2014·The Proceedings of the Nutrition Society·J RedmondI Schoenmakers
Jun 25, 2014·The Cochrane Database of Systematic Reviews·G Justus HofmeyrMaria R Torloni
Oct 25, 2014·Annals of Nutrition & Metabolism·John M Pettifor
Mar 19, 2015·American Journal of Therapeutics·Yulia Treister-Goltzman, Roni Peleg
Jun 23, 2015·Scientific Reports·Diriba B KumssaMartin R Broadley
Sep 17, 2015·Maternal & Child Nutrition·Rajneeta SarafCameron C Grant
Sep 20, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Anna A E VinkhuyzenJohn J McGrath
Jan 1, 2014·Dermato-endocrinology·U GröberK Kisters
Jan 19, 2016·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·M KielyÁ Hennessy
Feb 16, 2016·The Journal of Steroid Biochemistry and Molecular Biology·Cristina PalaciosJuan Pablo Peña-Rosas
May 6, 2016·The American Journal of Tropical Medicine and Hygiene·Yulia Treister-GoltzmanRoni Peleg
Jun 30, 2016·São Paulo Medical Journal = Revista Paulista De Medicina·Luz Maria De-RegilJuan Pablo Peña-Rosas
Nov 3, 2016·The American Journal of Clinical Nutrition·Charlotte MortensenChristian Mølgaard
Apr 14, 2017·The Cochrane Database of Systematic Reviews·Batool A Haider, Zulfiqar A Bhutta
Jun 18, 2017·Therapeutic Advances in Musculoskeletal Disease·Mairead KielyKaren M O'Callaghan
Nov 29, 2017·The Proceedings of the Nutrition Society·Karen M O'Callaghan, Mairead E Kiely

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Clinical Trials Mentioned

NCT02506439

Software Mentioned

SPSS

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