Interactions of 1-methyl-1,2,3,4-tetrahydroisoquinoline with lamotrigine, oxcarbazepine, pregabalin, and topiramate in the mouse maximal electroshock-induced seizure model: a type I isobolographic analysis

Epilepsy Research
Jarogniew J LuszczkiStanislaw J Czuczwar

Abstract

The aim of this study was to characterize the anticonvulsant effects of 1-methyl-1,2,3,4-tetrahydroisoquinoline (MeTHIQ--an endogenous parkinsonism-preventing substance) in combination with four second-generation antiepileptic drugs (AEDs: lamotrigine [LTG], oxcarbazepine [OXC], pregabalin [PGB], and topiramate [TPM]) in the mouse maximal electroshock (MES)-induced seizure model by using the type I isobolographic analysis for parallel and non-parallel dose-response relationship curves (DRRCs). Potential adverse-effect profiles of interactions of MeTHIQ with LTG, OXC, PGB and TPM at the fixed-ratio of 1:1 from the MES test with respect to motor performance, long-term memory and skeletal muscular strength were measured along with total brain concentrations of MeTHIQ and TPM. In the mouse MES model, MeTHIQ administered singly had its DRRC parallel to those for OXC and TPM, and simultaneously, non-parallel to those for LTG and PGB. With type I isobolography for parallel DRRCs, the combination of MeTHIQ with TPM at three fixed-ratios of 1:3, 1:1 and 3:1 exerted supra-additive (synergistic) interaction, whereas the combination of MeTHIQ with OXC at the fixed-ratios of 1:3, 1:1 and 3:1 produced additive interaction. Similarly, the typ...Continue Reading

References

Jul 20, 2001·Epilepsy Research·E Perucca, A Richens
Jul 17, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jarogniew J LuszczkiStanisław J Czuczwar
Feb 27, 2004·Naunyn-Schmiedeberg's Archives of Pharmacology·Jarogniew J Luszczki, Stanislaw J Czuczwar
Feb 18, 2005·Epilepsy Research·Richard P ShankMeir Bialer
Dec 13, 2005·Epilepsy Research·Mark G VartanianCharles P Taylor
Apr 11, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Jarogniew J LuszczkiStanislaw J Czuczwar
May 4, 2006·The Journal of Pharmacology and Experimental Therapeutics·Ronald J Tallarida
Feb 10, 2007·Neuropharmacology·David A MathersErnest Puil
Jan 29, 2008·Mini Reviews in Medicinal Chemistry·Giuseppe LatiniFrancesco Chiarelli

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Citations

Jan 8, 2015·Seizure : the Journal of the British Epilepsy Association·Eunice S M Yuen, Iñaki F Trocóniz
Aug 26, 2014·European Journal of Pharmacology·Nobuko Matsumura, Toshio Nakaki
Jun 3, 2021·International Journal of Molecular Sciences·Katarzyna Załuska-OgryzekJarogniew J Łuszczki

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