PMID: 3765346Jun 1, 1986Paper

Interactions of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) with immune responses of rainbow trout

Veterinary Immunology and Immunopathology
J M SpitsbergenR E Peterson

Abstract

Chlorinated dioxins, as typified by the most potent isomer, TCDD, are immunosuppressive in mammalian species and can enhance the susceptibility to a number of diseases. In recent years chlorinated dioxins have been detected in fish in many freshwater and marine habitats. Thus far, the effects of these chemicals on the immune responses of fish have not been examined. We studied the influence of TCDD on the defense mechanisms of rainbow trout. Yearling trout were injected intraperitoneally with the vehicle, 0.1, 1.0 or 10 micrograms/kg of TCDD. Interactions with the humoral immune response to sheep red blood cells (SRBC) were assessed by the Jerne plaque assay using head kidney and spleen leukocytes. Serum antibody was measured by complement-mediated lysis of SRBC in a chromium release assay. Effects of TCDD on the cellular immune responses were evaluated by the response of thymic and splenic lymphocytes to Con A and PWM. In addition, the phagocytic activity of peritoneal macrophages was examined in vitro. Trout which received 0.1 or 1.0 micrograms/kg TCDD remained clinically normal, and defense mechanisms were unaltered in these fish. Trout which received 10 micrograms/kg of TCDD became hypophagic and exhibited fin necrosis, asc...Continue Reading

References

May 1, 1977·CRC Critical Reviews in Toxicology·J G Vos
May 1, 1986·Toxicology and Applied Pharmacology·J M KleemanR E Peterson
Jan 1, 1982·Immunological Reviews·J L Turk, D Parker
Nov 1, 1981·Proceedings of the Society for Experimental Biology and Medicine·D A ClarkG Sweeney
Jan 1, 1983·Developmental and Comparative Immunology·D P AndersonE F Lizzio
Feb 1, 1982·Environmental Health Perspectives·J H DeanG A Boorman

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Citations

Oct 17, 2001·Developmental and Comparative Immunology·N C BolsL E Lee
Jan 1, 1988·Journal of Toxicology and Environmental Health·J M SpitsbergenR E Peterson
Jan 1, 1988·Journal of Toxicology and Environmental Health·J M SpitsbergenR E Peterson
Oct 1, 2011·Molecular and Cellular Endocrinology·Tisha C King-HeidenRichard E Peterson
Sep 4, 2020·International Journal of Molecular Sciences·Jun-Young SongHelmut Segner
Aug 8, 2021·International Journal of Molecular Sciences·Chisato Kataoka, Shosaku Kashiwada

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