Interactions of a Rhodococcus sp. biosurfactant trehalose lipid with phosphatidylethanolamine membranes

Biochimica Et Biophysica Acta
A OrtizF J Aranda

Abstract

Trehalose lipids are an important group of glycolipid biosurfasctants mainly produced by rhodococci. Beside their known industrial applications, there is an increasing interest in the use of these biosurfactants as therapeutic agents. We have purified a trehalose lipid from Rhodococcus sp. and made a detailed study of the effect of the glycolipid on the thermotropic and structural properties of phosphatidylethanolamine membranes of different chain length and saturation, using differential scanning calorimetry, small and wide angle X-ray diffraction and infrared spectroscopy. It has been found that trehalose lipid affects the gel to liquid crystalline phase transition of phosphatidylethanolamines, broadening and shifting the transition to lower temperatures. Trehalose lipid does not modify the macroscopic bilayer organization of saturated phosphatidylethanolamines and presents good miscibility both in the gel and the liquid crystalline phases. Infrared experiments evidenced an increase of the hydrocarbon chain conformational disorder and an important dehydrating effect of the interfacial region of the saturated phosphatidylethanolamines. Trehalose lipid, when incorporated into dielaidoylphosphatidylethanolamine, greatly promotes...Continue Reading

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Citations

Apr 29, 2010·Applied Microbiology and Biotechnology·Ibrahim M BanatRoger Marchant
Apr 8, 2014·Chemistry and Physics of Lipids·José A TeruelFrancisco J Aranda
Apr 5, 2011·Annual Review of Analytical Chemistry·Zachary D Schultz, Ira W Levin
Nov 6, 2015·Bioscience, Biotechnology, and Biochemistry·Takanori YanoNobuyuki Yoshida
Dec 3, 2008·Chemistry and Physics of Lipids·Antonio OrtizFrancisco J Aranda
May 24, 2011·Biochimica Et Biophysica Acta·Antonio OrtizFrancisco J Aranda
Jul 21, 2016·Critical Reviews in Food Science and Nutrition·Marcia Nitschke, Sumária Sousa E Silva
Mar 23, 2017·Organic Letters·Santanu JanaSuvarn S Kulkarni
Sep 13, 2020·Applied Microbiology and Biotechnology·Martina CappellettiDavide Zannoni
Jun 28, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Francisco CasadoFrancisco J Aranda
Feb 4, 2021·Biotechnology Letters·M Aguirre-RamírezM A Díaz De Rienzo
Apr 28, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Ana ZaragozaAntonio Ortiz
Feb 12, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Ana ZaragozaAntonio Ortiz
Oct 20, 2009·Journal of Colloid and Interface Science·Marina SánchezAntonio Ortiz

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